SCHEMBL7265346

SCHEMBL7265346

CCOC(=O)C1=C(C)NC(C)=C([N+](=O)[O-])C1c1ccccc1C(F)(F)F

nearest known ligand 0.80

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.80
CYP3A4 P08684 3/20 0.80
ADORA3 P0DMS8 3/20 0.80
MAPT P10636 3/20 0.80
CYP2C9 P11712 3/20 0.80
CYP2C19 P33261 3/20 0.80
CACNA1C Q13936 3/20 0.80
TSHR P16473 2/20 0.80
NFKB1 P19838 2/20 0.80
MEN1 O00255 1/20 0.80
CYP2D6 P10635 1/20 0.80
KMT2A Q03164 1/20 0.80
CACNA1F O60840 1/20 0.58
CACNA1D Q01668 1/20 0.58
CACNA1S Q13698 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11008471 0.92 CACNA1C (0.68) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL9674599 0.91 CYP1A2 (0.76) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL30897545 0.89 CYP1A2 (1.00) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL133106 0.89 CYP1A2 (1.00) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL2845539 0.89 CYP1A2 (1.00) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL718828 0.89 CYP1A2 (1.00) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL29359402 0.89 CYP1A2 (1.00) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL11008051 0.88 ADORA3 (0.72) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL10629270 0.88 CACNA1C (0.72) CYP1A2CYP3A4ADORA3MAPTCYP2C9
SCHEMBL7431826 0.88 CACNA1C (0.71) CACNA1CCACNA1FCACNA1DCACNA1S

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4920225-A Resolution of 1,4-dihydropyridine derivatives LABORATOIRES SYNTEX S.A. (FR) 1990-04-24 US disclosed
EP-0273349-A2 Resolution of 1,4-dihydropyridine derivatives LABORATOIRES SYNTEX S.A. (FR) 1988-07-06 EP disclosed