Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 5/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902945 | 0.80 | GRM5 (0.52) | KARS1GRM1MAP3K5LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL27662763 | 0.80 | KARS1 (0.47) | KARS1KMT2AKDM4ENPC1RAB9A | |
| SCHEMBL4902648 | 0.79 | SYK (0.39) | LMNAKMT2ATP53L3MBTL1KDM4E | |
| SCHEMBL6373788 | 0.79 | SLC2A1 (0.50) | GRM1LMNAKMT2ATP53KDM4E | |
| SCHEMBL4900205 | 0.78 | NPC1 (0.40) | KARS1LMNAKMT2ATP53L3MBTL1 | |
| SCHEMBL4901584 | 0.78 | SLC2A1 (0.48) | KARS1KMT2AL3MBTL1KDM4ENPC1 | |
| SCHEMBL4901969 | 0.78 | KARS1 (0.40) | KARS1LMNAKMT2AKDM4ENPC1 | |
| SCHEMBL5261849 | 0.78 | KARS1 (0.40) | KARS1MAP3K5LMNAKMT2ATP53 | |
| Hydrochloric Acid SCHEMBL4896691 | 0.77 | SLC2A1 (0.47) | KARS1KMT2AL3MBTL1KDM4ENPC1 | |
| Hydrochloric Acid SCHEMBL4900057 | 0.77 | KARS1 (0.39) | KARS1MAP3K5LMNAKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | KARS1 512/4885GRM1 484/4885MAP3K5 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.