Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KARS1 | Q15046 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4901584 | 0.83 | SLC2A1 (0.48) | NPC1RAB9AKMT2AMEN1KARS1 | |
| SCHEMBL4901969 | 0.83 | KARS1 (0.40) | NPC1RAB9AKMT2AMEN1KARS1 | |
| Hydrochloric Acid SCHEMBL27662763 | 0.82 | KARS1 (0.47) | NPC1RAB9AKMT2AMEN1KARS1 | |
| Hydrochloric Acid SCHEMBL4896691 | 0.82 | SLC2A1 (0.47) | NPC1RAB9AKMT2AMEN1KARS1 | |
| SCHEMBL4899168 | 0.81 | KARS1 (0.43) | NPC1RAB9AKARS1LMNASMN1; SMN2 | |
| SCHEMBL4902879 | 0.81 | KARS1 (0.52) | NPC1RAB9AKARS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5261849 | 0.80 | KARS1 (0.40) | NPC1RAB9AKMT2AKARS1RXFP1 | |
| Hydrochloric Acid SCHEMBL4900057 | 0.79 | KARS1 (0.39) | NPC1RAB9AKMT2AKARS1RXFP1 | |
| SCHEMBL4897013 | 0.78 | KARS1 (0.39) | NPC1RAB9AKMT2AMEN1KARS1 | |
| SCHEMBL3134265 | 0.78 | SLC2A1 (0.42) | NPC1RAB9AKMT2AMEN1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | ICAGEN, INC. (US) | 2008-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108600-A1 | Polycyclic Pyridines as Potassium Ion Channel Modulators | KCNJ2, KCNH2, KCNQ1 | NPC1 1509/4885RAB9A 3132/4885KMT2A 563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.