Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 3/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | RHOC | P08134 | 1/20 | 0.42 |
| ▸ | RHOA | P61586 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7566604 | 0.83 | GAA (0.61) | KCNH3 | |
| SCHEMBL6542384 | 0.83 | ALDH1A1 (0.57) | CNR1KCNH2MEN1MAPK1HTT | |
| SCHEMBL6542509 | 0.83 | ALDH1A1 (0.57) | CNR1KCNH2MEN1MAPK1HTT | |
| SCHEMBL12204424 | 0.78 | CYP19A1 (0.49) | CNR2CNR1CYP19A1PDE2AKCNH2 | |
| SCHEMBL8038878 | 0.77 | GAA (0.68) | CYP19A1MAPTMEN1MAPK1HTT | |
| SCHEMBL11205766 | 0.77 | ALDH1A1 (0.62) | MAPTMEN1MAPK1HTTKMT2A | |
| SCHEMBL2931121 | 0.77 | ALDH1A1 (0.62) | MAPTMEN1MAPK1HTTKMT2A | |
| SCHEMBL28676692 | 0.77 | GAA (0.61) | CNR2CNR1MAPTMEN1MAPK1 | |
| SCHEMBL10389939 | 0.77 | ALDH1A1 (0.62) | MAPTMEN1MAPK1HTTKMT2A | |
| SCHEMBL28277730 | 0.76 | PDE2A (0.47) | CNR2CNR1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080249180-A1 | MALONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249180-A1 | MALONAMIDES AS OREXIN ANTAGONISTS | HCRTR2, HCRTR1, MTNR1B | CNR2 19/4885CNR1 9/4885CYP19A1 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.