Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 10/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596875 | 0.90 | KIF11 (0.50) | KIF11SMN1; SMN2TDP2KMT2APARP1 | |
| SCHEMBL4596573 | 0.80 | KIF11 (0.51) | KIF11SMN1; SMN2TDP2KMT2APARP1 | |
| SCHEMBL14154358 | 0.76 | KIF11 (0.47) | KIF11SMN1; SMN2TDP2KMT2APARP1 | |
| SCHEMBL4898332 | 0.75 | KIF11 (0.51) | KIF11HRH3SMN1; SMN2TDP2KMT2A | |
| SCHEMBL4595034 | 0.73 | KIF11 (0.51) | KIF11HRH3TDP2KMT2AGAA | |
| SCHEMBL1396616 | 0.70 | KIF11 (1.00) | KIF11SMN1; SMN2TDP2AKT1 | |
| SCHEMBL4888947 | 0.70 | CYP11B1 (0.58) | KIF11TDP2BRD4KMT2AGAA | |
| SCHEMBL3315684 | 0.69 | HDAC6 (0.44) | KIF11HRH3TDP2SCN9A | |
| SCHEMBL4888856 | 0.69 | KIF11 (0.54) | KIF11TDP2KMT2AGAA | |
| SCHEMBL3307653 | 0.68 | KIF11 (0.78) | KIF11TDP2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176830-A1 | Compounds, Compositions, and Methods | ADAMS NICHOLAS D | 2008-07-24 | — | — | US | claimed |
| US-20080176830-A1 | Compounds, Compositions, and Methods | ADAMS NICHOLAS D | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176830-A1 | Compounds, Compositions, and Methods | ALPP, PCNA, MKI67 | KIF11 562/4885HRH3 4076/4885SMN1; SMN2 2221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.