Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.55 |
| ▸ | CASP7 | P55210 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | USP28 | Q96RU2 | 3/20 | 0.53 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4896350 | 0.85 | CHRM4 (0.75) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4898520 | 0.83 | USP28 (0.72) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4895561 | 0.83 | LMNA (0.61) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4890105 | 0.82 | CHRM4 (0.63) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4895200 | 0.82 | USP28 (0.65) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4896847 | 0.81 | LMNA (0.59) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4897719 | 0.81 | LMNA (0.59) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4887791 | 0.81 | LMNA (0.59) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4895317 | 0.81 | LMNA (0.59) | LMNACHRM4ALDH1A1MAPTNPC1 | |
| SCHEMBL4895313 | 0.81 | LMNA (0.59) | LMNACHRM4ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306107-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | claimed |
| CN-101128470-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | claimed |
| US-20080306107-A1 | Compounds | ASTRAZENECA AB (SE) | 2008-12-11 | — | — | US | disclosed |
| CN-101128470-A | Novel compounds | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306107-A1 | Compounds | FURIN, PCSK9, SLC10A1 | LMNA 27/4885CHRM4 942/4885ALDH1A1 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.