Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 5/20 | 0.63 |
| ▸ | THRB | P10828 | 5/20 | 0.63 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.47 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.47 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898942 | 0.93 | THRA (0.55) | THRATHRBPLA2G2AESR1KDM4E | |
| SCHEMBL8644661 | 0.89 | PLA2G2A (0.66) | THRATHRBPLA2G2AESR1TP53 | |
| SCHEMBL25788081 | 0.89 | PLA2G2A (0.66) | THRATHRBPLA2G2AESR1TP53 | |
| SCHEMBL2358713 | 0.89 | PLA2G2A (0.66) | THRATHRBPLA2G2AESR1TP53 | |
| SCHEMBL13617706 | 0.84 | THRA (0.63) | THRATHRBPLA2G2AESR1MEN1 | |
| SCHEMBL11343479 | 0.84 | THRA (0.63) | THRATHRBPLA2G2AESR1TP53 | |
| SCHEMBL9402785 | 0.83 | PLA2G2A (0.78) | PLA2G2ATP53TSHRPLA2G4BBLM | |
| SCHEMBL2309071 | 0.83 | ESR1 (0.75) | THRATHRBESR1ALDH1A1 | |
| SCHEMBL4891284 | 0.83 | PLA2G2A (0.54) | THRATHRBPLA2G2AESR1TP53 | |
| SCHEMBL1749419 | 0.81 | THRA (0.56) | THRATHRBPLA2G2AESR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080027096-A1 | Novel Pharmaceutical Compositions | KARO BIO AB (SE) | 2008-01-31 | — | — | US | disclosed |
| EP-1729756-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094810-A2 | NOVEL PHARMACEUTICAL COMPOSITIONS | KARO BIO AB (SE) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027096-A1 | Novel Pharmaceutical Compositions | AR, NR5A1, CYP17A1 | THRA 559/4885THRB 792/4885PLA2G2A 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.