SCHEMBL48989

SCHEMBL48989

CCC(CO)NC(C)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14970377 1.00
SCHEMBL5669163 1.00
SCHEMBL1861994 0.87
SCHEMBL422585 0.87
SCHEMBL14007401 0.81 PLA2G2C (0.40)
SCHEMBL1437055 0.80
SCHEMBL5197140 0.80
SCHEMBL4578510 0.80
SCHEMBL5112339 0.80
SCHEMBL2417291 0.79 TDP1 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1951686-B1 QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF HANMI PHARM IND CO LTD (KR) 2013-04-03 EP claimed
US-20080318950-A1 Quinazoline Derivatives as a Multiplex Inhibitor and Method For the Preparation Thereof HANMI PHARM. CO., LTD (KR) 2008-12-25 US claimed
CN-101304978-A Quinazoline derivatives as multiplex inhibitors and process for their preparation HANMI PHARM IND CO LTD (KR) 2008-11-12 CN claimed
EP-1951686-A1 QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF Hanmi Pharm. Co., Ltd. (KR) 2008-08-06 EP claimed
WO-2007055514-A1 QUINAZOLINE DERIVATIVES AS A MULTIPLEX INHIBITOR AND METHOD FOR THE PREPARATION THEREOF HANMI PHARM. CO., LTD. (KR) 2007-05-18 WO claimed
EP-4630410-A1 POLQ INHIBITORS Astrazeneca AB (SE) 2025-10-15 EP disclosed
CN-120020116-A Process for the preparation of N-alkenylamides 中国石油化工股份有限公司 2025-05-20 CN disclosed
WO-2024121753-A1 POLQ INHIBITORS ASTRAZENECA AB (SE) 2024-06-13 WO disclosed
WO-2023072974-A1 TRICYCLIC HETEROCYCLES MERCK PATENT GMBH (DE) 2023-05-04 WO disclosed
WO-2021224291-A1 TRICYCLIC HETEROCYCLES USEFUL AS TEAD BINDERS MERCK PATENT GMBH (DE) 2021-11-11 WO disclosed
EP-3089971-B1 COMPOUNDS AND METHODS OF USE MEDIVATION TECH LLC (US) 2020-07-29 EP disclosed
WO-2020012357-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE INTEGRAL BIOSCIENCES PVT. LTD. (IN) 2020-01-16 WO disclosed
EP-0239122-B1 PROCESS FOR THE ENZYMATIC RESOLUTION OF RACEMIC 2-AMINO-1-ALKANOLS Montedison S.p.A. (IT) 1992-06-17 EP disclosed
EP-0404146-A2 Enantiomeric enrichment and stereoselective synthesis of chiral amines CELGENE CORPORATION (US) 1990-12-27 EP disclosed
US-4950606-A CONTACTING IN AN AQUEOUS MEDIUM IN THE PRESENCE OF AN AMINO ACCEPTOR WITH AN OMEGA-AMINO ACID TRANSAMINASE TO CONVERT ONE OF AMINES TO KETONE CELGENE CORPORATION (US) 1990-08-21 US disclosed
EP-0239122-A2 Process for the enzymatic resolution of racemic 2-amino-1-alkanols Montedison S.p.A. (IT) 1987-09-30 EP disclosed
US-3944618-A DI-1-AMINO-2-BUTANOL, ETHYLENE DICHLORIDE AMERICAN CYANAMID COMPANY (US) 1976-03-16 US disclosed
US-3944619-A ISOLATION FROM L ISOMER USING L(+)-TARTARIC ACID AMERICAN CYANAMID COMPANY (US) 1976-03-16 US disclosed
US-3944617-A HYDROLYSIS OF N-(1-(CHLOROMETHYL)-PROPYL)ACETAMIDE AMERICAN CYANAMID COMPANY (US) 1976-03-16 US disclosed
US-3944608-A Synthesis of N-[1-(chloromethyl)propyl]acetamide AMERICAN CYANAMID COMPANY (US) 1976-03-16 US disclosed