Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906048 | 0.91 | ALDH1A1 (0.45) | ALDH1A1TSHRHCRTR2HDAC3HDAC11 | |
| SCHEMBL4908224 | 0.89 | HCRTR2 (0.39) | ALDH1A1TSHRHCRTR2GAAHPGD | |
| SCHEMBL4906634 | 0.88 | ALDH1A1 (0.40) | ALDH1A1TSHRNR1I2HCRTR2ADRB2 | |
| SCHEMBL4905613 | 0.88 | ALDH1A1 (0.48) | ALDH1A1TSHRCA2GAAHPGD | |
| SCHEMBL4894507 | 0.88 | ALDH1A1 (0.48) | ALDH1A1TSHRHCRTR2TP53GAA | |
| SCHEMBL4905552 | 0.86 | ALDH1A1 (0.41) | ALDH1A1TSHRMMP9MMP13GAA | |
| SCHEMBL4904399 | 0.85 | ALDH1A1 (0.46) | ALDH1A1TSHRHCRTR2TP53HDAC3 | |
| SCHEMBL4906296 | 0.85 | ALDH1A1 (0.48) | ALDH1A1TSHRHCRTR2GAAHPGD | |
| SCHEMBL4904025 | 0.84 | ALDH1A1 (0.45) | ALDH1A1TSHRMMP9MMP13TP53 | |
| SCHEMBL4902853 | 0.84 | ALDH1A1 (0.45) | ALDH1A1TSHRMMP9MMP13MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | ALDH1A1 2664/4885TSHR 412/4885NR1I2 66/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | ALDH1A1 2956/4885TSHR 400/4885NR1I2 68/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.