Sugi Predict

Sugi Predict / Compounds / SCHEMBL4905613

SCHEMBL4905613

SCHEMBL4905613

CCN(Sc1ccc(O)cc1)S(=O)(=O)c1ccc(C)c(C(=O)OC)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 7/20 0.48
▸ TSHR P16473 2/20 0.48
▸ MAPT P10636 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ ESR1 P03372 3/20 0.37
▸ CYP2C9 P11712 3/20 0.37
▸ KDM4E B2RXH2 2/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ CA2 P00918 3/20 0.36
▸ CA12 O43570 2/20 0.36
▸ CA1 P00915 2/20 0.36
▸ CA7 P43166 2/20 0.36
▸ CA9 Q16790 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4894507 0.91 ALDH1A1 (0.48) ALDH1A1TSHRMAPTHPGDGAA
SCHEMBL4906296 0.88 ALDH1A1 (0.48) ALDH1A1TSHRMAPTHPGDGAA
SCHEMBL4899260 0.88 ALDH1A1 (0.46) ALDH1A1TSHRMAPTHPGDGAA
SCHEMBL4902795 0.88 ALDH1A1 (0.42) ALDH1A1TSHRMAPTHPGDGAA
SCHEMBL4902853 0.87 ALDH1A1 (0.45) ALDH1A1TSHRMAPTKMT2AMEN1
SCHEMBL4904025 0.87 ALDH1A1 (0.45) ALDH1A1TSHRMAPTHPGDRAB9A
SCHEMBL4906048 0.87 ALDH1A1 (0.45) ALDH1A1TSHRMAPTGAAKMT2A
SCHEMBL4902656 0.86 LMNA (0.44) ALDH1A1TSHRMAPTGAAKMT2A
SCHEMBL4906314 0.86 ALDH1A1 (0.44) ALDH1A1TSHRMAPTKMT2AMEN1
SCHEMBL4905798 0.86 ALDH1A1 (0.44) ALDH1A1TSHRMAPTHPGDGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
EP-1765796-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS Pfizer Products Inc. (US) 2007-03-28 — — EP disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
WO-2006003495-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER PRODUCTS INC. (US) 2006-01-12 — — WO disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD ALDH1A1 2664/4885TSHR 412/4885MAPT 1858/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ALDH1A1 2956/4885TSHR 400/4885MAPT 1786/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD ALDH1A1 2956/4885TSHR 400/4885MAPT 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.