Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.31 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.31 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11479394 | 0.87 | ALDH1A1 (0.49) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11482442 | 0.81 | MAPT (0.48) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL4895941 | 0.79 | MAPT (0.64) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11475899 | 0.79 | MAPT (0.49) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11477655 | 0.79 | MAPT (0.49) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11479625 | 0.79 | MAPT (0.49) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL4898995 | 0.79 | MAPT (0.39) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL4903231 | 0.77 | CLK1 (0.49) | ALDH1A1KDM4ENPC1MEN1KMT2A | |
| SCHEMBL4900007 | 0.72 | KDM4E (0.46) | ALDH1A1MAPTKDM4EHPGDNPC1 | |
| SCHEMBL11098038 | 0.69 | MAPT (0.48) | ALDH1A1MAPTKDM4EHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4239887-A | ANTIALLERGENS | USV PHARMACEUTICAL CORPORATION (US) | 1980-12-16 | — | — | US | claimed |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | CYWIN CHARLES L | 2008-01-10 | — | — | US | disclosed |
| US-7291733-B2 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-11-06 | — | — | US | disclosed |
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | US | disclosed |
| US-4239887-A | ANTIALLERGENS | USV PHARMACEUTICAL CORPORATION (US) | 1980-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101601-A1 | Substituted tricyclic heterocycles and their uses | LTC4S, NQO1, CBR3 | ALDH1A1 270/4885MAPT 4573/4885KDM4E 3715/4885 |
| US-20080008720-A1 | Substituted Tricyclic Heterocycles and their Uses | LTC4S, NQO1, CBR3 | ALDH1A1 270/4885MAPT 4573/4885KDM4E 3715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.