SCHEMBL4899524

SCHEMBL4899524

CNC(=O)Nc1cc(C(C)(C)C)on1.CNC(=O)Nc1cc(C(C)(C)C)on1

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.66
KMT2A Q03164 3/20 0.66
MEN1 O00255 2/20 0.66
NPC1 O15118 2/20 0.66
MAPK14 Q16539 4/20 0.64
EGFR P00533 1/20 0.62
GAA P10253 1/20 0.60
MAPT P10636 2/20 0.59
HTT P42858 2/20 0.59
NPSR1 Q6W5P4 1/20 0.59
EPHX2 P34913 2/20 0.58
ATM Q13315 1/20 0.58
RAF1 P04049 4/20 0.58
FLT3 P36888 3/20 0.57
MAPK13 O15264 1/20 0.56
MAPK12 P53778 1/20 0.56
MAPK11 Q15759 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL134635 1.00 RAB9A (0.66) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL2951112 0.91 RAB9A (0.77) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL14379217 0.85 RAB9A (0.64) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL10202278 0.85 RAB9A (0.64) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL20922052 0.84 MAPK14 (0.50) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL10809541 0.84 RAB9A (0.49) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL11119624 0.83 RAB9A (0.62) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL10800807 0.83 GAA (0.48) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL4112548 0.82 EGFR (0.66) RAB9AKMT2AMEN1NPC1MAPK14
SCHEMBL1758718 0.82 EGFR (0.66) RAB9AKMT2AMEN1NPC1MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3906245-B1 MULTIFUNCTIONAL ORGANOSILICON COMPOUND AND RELATED METHODS, COMPOUNDS, AND COMPOSITIONS DOW SILICONES CORP (US) 2024-05-29 EP disclosed
EP-3645640-B1 SILICONE-POLYETHER COPOLYMER, METHOD OF PREPARING SAME, AND SEALANT COMPRISING SAME DOW SILICONES CORP (US) 2024-03-06 EP disclosed
WO-2023215360-A1 SILICONE-POLYETHER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION (US) 2023-11-09 WO disclosed
US-11807775-B2 Silicone-organic copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-11-07 US disclosed
US-11760841-B2 Silicone-polycarbonate copolymer, sealants comprising same, and related methods DOW SILICONES CORPORATION (US) 2023-09-19 US disclosed
EP-3898779-B1 SILICONE-POLYESTER COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORP (US) 2023-02-08 EP disclosed
EP-3898781-B1 SILICONE-POLYCARBONATE COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORP (US) 2023-01-04 EP disclosed
US-20220064383-A1 SILICONE-POLYACRYLATE COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION 2022-03-03 US disclosed
US-20220064482-A1 SILICONE-ORGANIC COPOLYMER, SEALANTS COMPRISING SAME, AND RELATED METHODS DOW SILICONES CORPORATION 2022-03-03 US disclosed
EP-3906245-A1 MULTIFUNCTIONAL ORGANOSILICON COMPOUND AND RELATED METHODS, COMPOUNDS, AND COMPOSITIONS Dow Silicones Corporation (US) 2021-11-10 EP disclosed
US-20140171547-A1 Bismuth Containing Complex and Condensation Reaction Curable Compositions and Methods for the Preparation and Use of the Compositions DOW CORNING CORPORATION 2014-06-19 US disclosed
US-20140135517-A1 Hydrosilylation Reaction Curable Compositions And Methods For Their Preparation And Use DOW CORNING CORPORATION (US) 2014-05-15 US disclosed
US-20140100347-A1 Metal Containing Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts DOW SILICONES CORPORATION 2014-04-10 US disclosed
WO-2014021908-A1 IRIDIUM CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2014-02-06 WO disclosed
US-20140039089-A1 Compositions Containing Phosphonate Catalysts And Methods For The Preparation And Use Of The Compositions DOW CORNING CORPORATION (US) 2014-02-06 US disclosed
US-20140018467-A1 COMPOSITIONS CONTAINING SULFONIC ACID CATALYSTS AND METHODS FOR THE PREPARATION AND USE OF THE COMPOSITIONS DOW CORNING CORPORATION (US) 2014-01-16 US disclosed
WO-2013043767-A2 RHENIUM CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-03-28 WO disclosed
WO-2013043912-A2 IRON CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-03-28 WO disclosed
WO-2013043764-A2 SILVER CONTAINING HYDROSILYLATION CATALYSTS AND COMPOSITIONS CONTAINING THE CATALYSTS DOW CORNING CORPORATION (US) 2013-03-28 WO disclosed
US-20080118734-A1 Coating Compositions DOW CORNING IRELAND LTD. (IE) 2008-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140135517-A1 Hydrosilylation Reaction Curable Compositions And Methods For Their Preparation And Use HIRA, HIRIP3, CROCC RAB9A 2718/4885KMT2A 1878/4885MEN1 1410/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.