Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.61 |
| ▸ | CHUK | O15111 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 6/20 | 0.60 |
| ▸ | PRKCA | P17252 | 4/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.60 |
| ▸ | BCR | P11274 | 5/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893321 | 0.90 | ABL1 (0.69) | IKBKBCHUKABL1PRKCAEGFR | |
| SCHEMBL4903401 | 0.89 | IKBKB (0.67) | IKBKBCHUKPLK1PIK3CAPIK3CB | |
| SCHEMBL4892544 | 0.87 | KIT (0.69) | ABL1PRKCAEGFRBCRKIT | |
| SCHEMBL4138273 | 0.86 | ABL1 (0.57) | IKBKBABL1PRKCAEGFRPRKCD | |
| SCHEMBL4146725 | 0.84 | ABL1 (0.66) | IKBKBABL1PRKCAEGFRPRKCD | |
| SCHEMBL4901606 | 0.83 | IKBKB (0.57) | IKBKBCHUKABL1PRKCABCR | |
| SCHEMBL7470673 | 0.81 | IKBKB (0.81) | IKBKBABL1PRKCAEGFRPRKCD | |
| SCHEMBL4903409 | 0.81 | IKBKB (0.61) | IKBKBCHUKABL1PRKCAPRKCD | |
| SCHEMBL4897551 | 0.80 | ABL1 (0.69) | IKBKBABL1PRKCAEGFRPRKCD | |
| SCHEMBL4903706 | 0.79 | PRKCA (0.70) | ABL1PRKCAEGFRBCRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | IKBKB 875/4885CHUK 597/4885ABL1 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.