Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6230636 | 0.89 | ALDH1A1 (0.68) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| Citric Acid SCHEMBL4900009 | 0.87 | ALDH1A1 (0.71) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL4899158 | 0.84 | ALDH1A1 (0.75) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL2150983 | 0.82 | ALDH1A1 (0.79) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL275783 | 0.80 | ALDH1A1 (0.75) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL1871341 | 0.80 | ALDH1A1 (0.83) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL9795594 | 0.80 | ALDH1A1 (0.83) | ALDH1A1LMNAMEN1KMT2AALKBH5 | |
| Citric Acid SCHEMBL182590 | 0.80 | ALDH1A1 (0.83) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| Citric Acid SCHEMBL7369132 | 0.80 | ALDH1A1 (0.83) | ALDH1A1LMNAMEN1KMT2AKDM4E | |
| Citric Acid SCHEMBL119740 | 0.80 | ALDH1A1 (0.83) | ALDH1A1LMNAMEN1KMT2AALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080175964-A1 | Method for making bleached soy fiber | SUNOPTA INC. (CA) | 2008-07-24 | — | — | US | disclosed |