Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | ACR | P10323 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27823092 | 0.71 | MEN1 (0.66) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL29920925 | 0.71 | MEN1 (0.66) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL5245392 | 0.71 | KIF11 (0.53) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL4763588 | 0.70 | KIF11 (0.51) | KIF11MEN1KMT2AKDM4E | |
| SCHEMBL4316832 | 0.70 | KIF11 (0.89) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL2941623 | 0.69 | CES2 (0.44) | MEN1KMT2AKDM4ECES2 | |
| SCHEMBL28909073 | 0.68 | KIF11 (0.86) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL28868760 | 0.68 | KIF11 (0.49) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL4901404 | 0.68 | KIF11 (0.45) | KIF11MEN1KMT2APRSS1ACR | |
| SCHEMBL14785293 | 0.67 | KIF11 (0.47) | KIF11MEN1KMT2APRSS1ACR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |