Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.50 |
| ▸ | PDE5A | O76074 | 9/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741016 | 0.82 | PDE5A (0.58) | TERTPDE5A | |
| SCHEMBL1706222 | 0.82 | TERT (0.49) | TERTPDE5A | |
| SCHEMBL1705329 | 0.82 | TERT (0.61) | TERTPDE5A | |
| SCHEMBL13990468 | 0.80 | TERT (0.53) | TERTPDE5A | |
| SCHEMBL8055436 | 0.80 | PDE5A (0.56) | TERTPDE5A | |
| SCHEMBL5739554 | 0.79 | TERT (0.50) | TERTPDE5APDE3BPDE3A | |
| SCHEMBL8125815 | 0.78 | TERT (0.62) | TERTPDE5APDE3BPDE3A | |
| SCHEMBL8055439 | 0.77 | TERT (0.54) | TERTPDE5A | |
| SCHEMBL4565717 | 0.77 | TERT (0.56) | TERTPDE5APDE3BPDE3A | |
| SCHEMBL7253729 | 0.77 | TERT (0.58) | TERTPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194529-A1 | HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS | PDE5A, PDE7A, PDE3A | TERT 3651/4885PDE5A 1/4885PDE3B 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.