SCHEMBL4902264

SCHEMBL4902264

C=COC(=O)c1ccc(OC(=O)CC)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
ESR1 P03372 2/20 0.60
HIF1A Q16665 2/20 0.60
RECQL P46063 1/20 0.60
ELANE P08246 1/20 0.55
MAPT P10636 4/20 0.43
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
MEN1 O00255 2/20 0.41
HTT P42858 2/20 0.41
ACHE P22303 1/20 0.41
GAA P10253 1/20 0.41
THRB P10828 1/20 0.41
ALDH1A1 P00352 2/20 0.40
MGLL Q99685 1/20 0.40
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
LMNA P02545 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317925 0.88 BCL9 (0.50) KMT2ASMN1; SMN2ESR1HIF1ARECQL
SCHEMBL9259499 0.84 HTT (0.44) KMT2ASMN1; SMN2ESR1HIF1ARECQL
SCHEMBL4902491 0.81 ELANE (0.53) KMT2ASMN1; SMN2ESR1RECQLELANE
SCHEMBL14903557 0.80 KMT2A (0.64) KMT2ASMN1; SMN2ESR1HIF1ARECQL
SCHEMBL758958 0.80 PARP10 (0.56) KMT2ASMN1; SMN2MAPTNPC1RAB9A
SCHEMBL27511903 0.80 KMT2A (0.68) KMT2ASMN1; SMN2ESR1HIF1ARECQL
SCHEMBL12904282 0.80 THRB (0.49) KMT2ASMN1; SMN2MAPTRAB9AMEN1
SCHEMBL31443226 0.79 ELANE (0.57) KMT2ASMN1; SMN2ESR1HIF1ARECQL
SCHEMBL28447830 0.79 KMT2A (0.59) KMT2ASMN1; SMN2MAPTMEN1GAA
Benzoic Acid Vinyl Ester SCHEMBL3741502 0.79 LMNA (0.46) KMT2AHIF1AELANEMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080003288-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2008-01-03 US disclosed
US-7204997-B2 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2007-04-17 US disclosed
EP-1478403-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA, INC. (CA) 2004-11-24 EP disclosed
US-20030152623-A1 Responsive microgel and methods related thereto SUPRATEK PHARMA INC. (CA) 2003-08-14 US disclosed
WO-2003063909-A1 RESPONSIVE MICROGEL AND METHODS RELATED THERETO SUPRATEK PHARMA INC. (US) 2003-08-07 WO disclosed
EP-0910351-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-28 EP disclosed
EP-0907666-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. Searle & Co. (US) 1999-04-14 EP disclosed
WO-1997049736-A2 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed
WO-1997049387-A1 PARTICLES COMPRISING AMPHIPHILIC COPOLYMERS, HAVING A CROSS-LINKED SHELL DOMAIN AND AN INTERIOR CORE DOMAIN, USEFUL FOR PHARMACEUTICAL AND OTHER APPLICATIONS G.D. SEARLE AND CO. (US) 1997-12-31 WO disclosed