Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | EIF4E | P06730 | 17/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902676 | 0.91 | ALDH1A1 (0.44) | LMNAEIF4EALDH1A1 | |
| SCHEMBL4905513 | 0.90 | EIF4E (0.43) | LMNAEIF4E | |
| SCHEMBL4906585 | 0.90 | LMNA (0.43) | LMNAEIF4EALDH1A1HPGDALOX15 | |
| SCHEMBL4899849 | 0.88 | LMNA (0.46) | LMNAEIF4EALDH1A1HPGDALOX15 | |
| SCHEMBL4906638 | 0.86 | ALDH1A1 (0.44) | LMNAEIF4EALDH1A1HPGDALOX15 | |
| SCHEMBL4907121 | 0.86 | LMNA (0.47) | LMNAEIF4EALDH1A1HPGDALOX15 | |
| SCHEMBL4895709 | 0.84 | TP53 (0.43) | LMNAEIF4EALDH1A1HPGDALOX15 | |
| SCHEMBL4901081 | 0.83 | LMNA (0.62) | LMNAALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL4898066 | 0.83 | ALDH1A1 (0.39) | LMNAEIF4EALDH1A1 | |
| SCHEMBL4906525 | 0.83 | LMNA (0.47) | LMNAEIF4EALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LMNA 319/4885EIF4E 3036/4885ALDH1A1 2956/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LMNA 319/4885EIF4E 3036/4885ALDH1A1 2956/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.