Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL4910924 | 0.93 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| SCHEMBL4903312 | 0.88 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| Dimethylamine SCHEMBL4913721 | 0.84 | SMN1; SMN2 (0.40) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| SCHEMBL4903308 | 0.82 | ALDH1A1 (0.39) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| Dimethylamine SCHEMBL4906846 | 0.82 | MAPT (0.37) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| SCHEMBL4910918 | 0.82 | PDGFRA (0.36) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| SCHEMBL4910912 | 0.75 | MAPT (0.38) | ALDH1A1MAPTKMT2AGAAKDM4E | |
| Dimethylamine SCHEMBL4911507 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MAPTKMT2AKDM4EMEN1 | |
| SCHEMBL4913718 | 0.72 | ALDH1A1 (0.39) | ALDH1A1KMT2AKDM4ESMN1; SMN2CYP3A4 | |
| SCHEMBL4906843 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTKMT2AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
| WO-2004014906-A2 | NITRO AND AMINO SUBSTITUTED DIBENZONAPHTHYRIDINES AS TOPOISOMERASE AGENTS | RUTGERS, THE STATE UNIVERSITY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | ALDH1A1 2380/4885MAPT 4024/4885KMT2A 1248/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | ALDH1A1 1476/4885MAPT 4283/4885KMT2A 1259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.