Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.81 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.81 |
| ▸ | ABL1 | P00519 | 11/20 | 0.69 |
| ▸ | PRKCA | P17252 | 5/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.69 |
| ▸ | EGFR | P00533 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.67 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.64 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.64 |
| ▸ | BCR | P11274 | 10/20 | 0.63 |
| ▸ | CDK4 | P11802 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | ABL2 | P42684 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 5/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | PRKACG | P22612 | 1/20 | 0.60 |
| ▸ | PRKACB | P22694 | 1/20 | 0.60 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246523 | 0.90 | MAPK8 (1.00) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL210190 | 0.88 | ABL1 (0.76) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| Hydrochloric Acid SCHEMBL7470853 | 0.87 | ABL1 (0.74) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL7467179 | 0.87 | ABL1 (0.69) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL7470849 | 0.87 | ABL1 (0.69) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL4903457 | 0.87 | MAPK8 (0.81) | MAPK8MAPK10ABL1HDAC1ACVR1 | |
| SCHEMBL4895454 | 0.86 | ABL1 (0.80) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| Hydrochloric Acid SCHEMBL27711429 | 0.85 | ABL1 (0.79) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL7474316 | 0.85 | HDAC1 (0.68) | MAPK8MAPK10ABL1PRKCAPRKCD | |
| SCHEMBL4073695 | 0.85 | MAPK8 (0.65) | MAPK8MAPK10ABL1PRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | claimed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | claimed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | claimed |
| US-20080187575-A1 | Pyrimidine Derivatives | VICHEM CHEMIE KFT (HU) | 2008-08-07 | — | — | US | disclosed |
| CN-101155786-A | N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof | IL YANG PHARM CO LTD (KR) | 2008-04-02 | — | — | CN | disclosed |
| EP-1786781-A2 | PYRIMIDINE DERIVATIVES | GPC Biotech AG (DE) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006021458-A2 | PYRIMIDINE DERIVATIVES | GPC BIOTECH AG (DE) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080187575-A1 | Pyrimidine Derivatives | TYMP, TDP1, PNP | MAPK8 3140/4885MAPK10 2491/4885ABL1 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.