Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KDM6B | O15054 | 1/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.57 |
| ▸ | KDM5C | P41229 | 1/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.57 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.57 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.57 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | KMO | O15229 | 2/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31301228 | 0.86 | CHEK2 (0.59) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL28334001 | 0.86 | CHEK2 (0.59) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL28830424 | 0.83 | KDM4E (0.64) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL29800516 | 0.83 | KDM4E (0.69) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL28404844 | 0.83 | KDM4E (0.64) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL207017 | 0.83 | KDM4E (0.69) | KDM4EKDM6BKDM4AKDM5CKDM4C | |
| SCHEMBL31390061 | 0.83 | KCNK3 (0.53) | TGFBR1 | |
| SCHEMBL11185348 | 0.82 | KDM4E (0.49) | KDM4ECYP2A6ALDH1A1GAACHEK2 | |
| SCHEMBL3715357 | 0.81 | LDHA (0.57) | KMOMKNK1MKNK2LDHADHODH | |
| SCHEMBL1319171 | 0.81 | MKNK1 (0.53) | KDM4ECYP2A6KMOMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269214-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269214-A1 | Pyrrole Derivatives as Dna Gyrase and Topoisomerase Inhibitors | TOP1, TOP2A, TOP2B | KDM4E 1366/4885KDM6B 1707/4885KDM4A 2010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.