Sugi Predict

Sugi Predict / Compounds / SCHEMBL4903867

SCHEMBL4903867

SCHEMBL4903867

COC(=O)c1cc(S(=O)(=O)NCCOc2ccc(C(F)(F)F)cc2)cc(C)c1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.46
▸ ALDH1A1 P00352 4/20 0.44
▸ HPGD P15428 2/20 0.41
▸ LMNA P02545 2/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ HTT P42858 3/20 0.41
▸ NPSR1 Q6W5P4 2/20 0.40
▸ GAA P10253 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ RHOC P08134 1/20 0.39
▸ RHOA P61586 1/20 0.39
▸ IDH1 O75874 1/20 0.39
▸ CA12 O43570 1/20 0.39
▸ CA1 P00915 1/20 0.39
▸ CA2 P00918 1/20 0.39
▸ ADRB2 P07550 1/20 0.39
▸ ADRB1 P08588 1/20 0.39
▸ CA9 Q16790 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4901782 0.92 TDP1 (0.47) TDP1ALDH1A1MEN1KMT2AHTT
SCHEMBL4900998 0.91 TDP1 (0.47) TDP1ALDH1A1HPGDLMNASMN1; SMN2
SCHEMBL4904407 0.91 SMN1; SMN2 (0.48) TDP1ALDH1A1LMNASMN1; SMN2MEN1
SCHEMBL4894408 0.87 ERBB2 (0.51) ALDH1A1SMN1; SMN2
SCHEMBL4906408 0.85 ALDH1A1 (0.44) ALDH1A1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL4908897 0.85 ALDH1A1 (0.45) ALDH1A1LMNAMEN1KMT2AHTT
SCHEMBL4899554 0.85 ALDH1A1 (0.42) ALDH1A1HPGDLMNASMN1; SMN2MEN1
SCHEMBL4904258 0.83 TDP1 (0.47) TDP1ALDH1A1LMNAMEN1KMT2A
SCHEMBL4895638 0.83 ERBB2 (0.44) ALDH1A1LMNASMN1; SMN2MEN1KMT2A
SCHEMBL4908583 0.81 HTT (0.48) TDP1ALDH1A1LMNASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD TDP1 3363/4885ALDH1A1 2664/4885HPGD 696/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD TDP1 3653/4885ALDH1A1 2956/4885HPGD 724/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD TDP1 3653/4885ALDH1A1 2956/4885HPGD 724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.