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SCHEMBL4904258

SCHEMBL4904258

Cc1cc(S(=O)(=O)NCCOc2ccc(OC(F)(F)F)cc2)cc(C(=O)O)c1C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 1/20 0.47
▸ ALDH1A1 P00352 4/20 0.46
▸ MEN1 O00255 1/20 0.45
▸ HTT P42858 1/20 0.45
▸ KMT2A Q03164 1/20 0.45
▸ CA12 O43570 1/20 0.42
▸ CA1 P00915 1/20 0.42
▸ CA2 P00918 1/20 0.42
▸ ADRB2 P07550 1/20 0.42
▸ ADRB1 P08588 1/20 0.42
▸ CA9 Q16790 1/20 0.42
▸ FFAR4 Q5NUL3 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ NPSR1 Q6W5P4 1/20 0.42
▸ MMP2 P08253 2/20 0.41
▸ MMP9 P14780 2/20 0.41
▸ MMP14 P50281 2/20 0.41
▸ ADAM17 P78536 2/20 0.41
▸ MMP1 P03956 1/20 0.41
▸ EPHX2 P34913 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4901782 0.92 TDP1 (0.47) TDP1ALDH1A1MEN1HTTKMT2A
SCHEMBL4900998 0.91 TDP1 (0.47) TDP1ALDH1A1MEN1HTTKMT2A
SCHEMBL4908583 0.87 HTT (0.48) TDP1ALDH1A1MEN1HTTKMT2A
SCHEMBL4905342 0.87 ALDH1A1 (0.44) ALDH1A1MEN1HTTKMT2AFFAR4
SCHEMBL4904440 0.85 LTA4H (0.47) ALDH1A1MEN1KMT2AFFAR4L3MBTL1
SCHEMBL4897453 0.85 AKR1C3 (0.46) ALDH1A1MEN1KMT2AFFAR4EPHX2
SCHEMBL4902541 0.84 ALDH1A1 (0.42) ALDH1A1MEN1HTTKMT2AFFAR4
SCHEMBL4903867 0.83 TDP1 (0.46) TDP1ALDH1A1MEN1HTTKMT2A
SCHEMBL4904407 0.80 SMN1; SMN2 (0.48) TDP1ALDH1A1MEN1HTTKMT2A
SCHEMBL5371846 0.80 POLB (0.53) FFAR4LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD TDP1 3363/4885ALDH1A1 2664/4885MEN1 4859/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD TDP1 3653/4885ALDH1A1 2956/4885MEN1 4855/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD TDP1 3653/4885ALDH1A1 2956/4885MEN1 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.