Sugi Predict

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SCHEMBL4903885

SCHEMBL4903885

Cc1ccc(S(=O)(=O)NCCSc2ccc(Oc3ccccc3)cc2)cc1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.57
▸ ALDH1A1 P00352 9/20 0.55
▸ MAPT P10636 1/20 0.55
▸ TSHR P16473 5/20 0.53
▸ HSD17B10 Q99714 1/20 0.53
▸ HTT P42858 2/20 0.49
▸ POLB P06746 2/20 0.48
▸ MMP2 P08253 2/20 0.47
▸ ADAMTS4 O75173 1/20 0.47
▸ MMP13 P45452 1/20 0.47
▸ MMP14 P50281 1/20 0.47
▸ ADAMTS5 Q9UNA0 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ CYP2C9 P11712 2/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ CYP2C19 P33261 1/20 0.46
▸ NR1H4 Q96RI1 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ CA12 O43570 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4898259 0.94 ALDH1A1 (0.57) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4894428 0.93 POLB (0.58) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4902649 0.93 ALDH1A1 (0.54) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4905712 0.93 LMNA (0.51) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4905961 0.92 ALDH1A1 (0.57) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4906509 0.92 ALDH1A1 (0.57) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4905287 0.91 LMNA (0.49) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4905229 0.90 LMNA (0.48) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4904686 0.90 LMNA (0.51) LMNAALDH1A1MAPTTSHRHSD17B10
SCHEMBL4899879 0.89 LMNA (0.48) LMNAALDH1A1MAPTTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885ALDH1A1 2664/4885MAPT 1858/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885MAPT 1786/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885MAPT 1786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.