Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | GSR | P00390 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11854423 | 0.91 | HMGCR (0.44) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL11377918 | 0.89 | HMGCR (0.43) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL4145721 | 0.86 | HMGCR (0.54) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL490563 | 0.86 | HMGCR (0.57) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL16691053 | 0.84 | HMGCR (0.49) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL11777977 | 0.84 | HMGCR (0.40) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL11017356 | 0.83 | HMGCR (0.51) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL2671331 | 0.83 | HMGCR (0.53) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL9126198 | 0.81 | HMGCR (0.51) | HMGCRGAAALDH1A1TSHRKMT2A | |
| SCHEMBL4830853 | 0.81 | HMGCR (0.49) | HMGCRGAAALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268293-B2 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2012-09-18 | — | — | US | disclosed |
| CN-101163659-B | Antioxidants | MERCK PATENT GMBH | 2012-09-05 | — | — | CN | disclosed |
| US-8106233-B2 | Applying di-2-ethylhexyl 4-hydroxy-3,5-dimethoxy-benzylmalonate; protective action against UV rays, oxidative stress on body cells, counters skin ageing | MERCK PATENT GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | MERCK PATENT GMBH (DE) | 2008-07-17 | — | — | US | disclosed |
| US-20080152603-A1 | Antioxidants | SUSONITY Commercial GmbH (DE) | 2008-06-26 | — | — | US | disclosed |
| CN-101163659-A | Antioxidants | MERCK PATENT GMBH (DE) | 2008-04-16 | — | — | CN | disclosed |
| EP-1871339-A1 | UV PROTECTION | Merck Patent GmbH (DE) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871735-A1 | ANTIOXIDANTS | Merck Patent GmbH (DE) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006111233-A1 | ANTIOXIDANTS | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |
| WO-2006111234-A1 | UV PROTECTION | MERCK PATENT GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |
| EP-1027335-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | Cerebrus Pharmaceuticals Limited (GB) | 2000-08-16 | — | — | EP | disclosed |
| EP-1006108-A1 | 3-Hydroxy-2(1H)-pyridinone or 3-hydroxy-4(1H)-pyridinone derivatives useful as reactive oxygen species (ROS) scavengers | Cerebrus Pharmaceuticals Limited (GB) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999023075-A1 | ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS | CEREBRUS PHARMACEUTICALS LIMITED (GB) | 1999-05-14 | — | — | WO | disclosed |
| EP-0019578-B1 | PIPERIDINE DERIVATIVES, PROCESS FOR PREPARING THEM AND POLYMER COMPOSITIONS CONTAINING THEM | Chimosa Chimica Organica S.p.A. (IT) | 1983-03-30 | — | — | EP | disclosed |
| US-4316025-A | STABVILIZERS FOR POLYMERS | CHIMOSA CHIMICA ORGANICA S.P.A. (IT) | 1982-02-16 | — | — | US | disclosed |
| EP-0019578-A1 | Piperidine derivatives, process for preparing them and polymer compositions containing them | Chimosa Chimica Organica S.p.A. (IT) | 1980-11-26 | — | — | EP | disclosed |
| US-3989738-A | Method of preparing phenolic antioxidants by condensing active methylene compounds with 3,5-di-tert alkyl-4-hydroxybenzylpyridinium salts | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1976-11-02 | — | — | US | disclosed |
| US-3951915-A | Thermo-oxidative stable copolyesters | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1976-04-20 | — | — | US | disclosed |
| US-3943106-A | POLYESTERS AND POLYAMIDS FROM HYDROXYBENZYLMALONIC ACID DERIVATIVES; STABILIZERS | CIBA-GEIGY CORPORATION (US) | 1976-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080152603-A1 | Antioxidants | GPX4, GPX1, CAT | HMGCR 373/4885GAA 940/4885ALDH1A1 181/4885 |
| US-20080171004-A1 | Using compounds which do not themselves exhibit significant UV absorption in the UV-A or UV-B region, but are reactive under use conditions, such as 4-hydroxyphenylpropionic acid, or 2-ethylhexyl 4-hydroxy-3,5-dimethoxycinnamate, or polysiloxanes which contain benzylidenemalonic acid derivatives | HPD, HAAO, UGT1A6 | HMGCR 637/4885GAA 309/4885ALDH1A1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.