Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4899803 | 0.94 | HCRTR2 (0.53) | HCRTR2NR3C1NPSR1ALDH1A1KDM4E | |
| SCHEMBL4906502 | 0.91 | HDAC8 (0.50) | HCRTR2NPSR1ALDH1A1LMNATSHR | |
| SCHEMBL4907142 | 0.91 | HCRTR2 (0.54) | HCRTR2NR3C1ALDH1A1KDM4EPKM | |
| SCHEMBL4903860 | 0.90 | HCRTR2 (0.51) | HCRTR2NR3C1NPSR1ALDH1A1KDM4E | |
| SCHEMBL4903997 | 0.90 | MAPT (0.49) | NR3C1NPSR1ALDH1A1LMNATSHR | |
| SCHEMBL4904184 | 0.89 | HCRTR2 (0.50) | HCRTR2NR3C1NPSR1ALDH1A1KDM4E | |
| SCHEMBL4903818 | 0.89 | ESR1 (0.52) | NR3C1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4902668 | 0.89 | ALDH1A1 (0.46) | NR3C1NPSR1ALDH1A1LMNATSHR | |
| SCHEMBL4907631 | 0.88 | LMNA (0.55) | HCRTR2ALDH1A1KDM4EPKMLMNA | |
| SCHEMBL4895843 | 0.88 | ALDH1A1 (0.50) | NR3C1ALDH1A1LMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | HCRTR2 3933/4885NR3C1 169/4885NPSR1 735/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | HCRTR2 3933/4885NR3C1 169/4885NPSR1 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.