Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.33 |
| ▸ | ITGAL | P20701 | 3/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905313 | 1.00 | MCHR1 (0.36) | MCHR1CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4637406 | 1.00 | MCHR1 (0.36) | MCHR1CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4912813 | 0.89 | CCR5 (0.38) | ITGB2ICAM1ITGALMEN1KMT2A | |
| SCHEMBL4637355 | 0.89 | CCR5 (0.38) | ITGB2ICAM1ITGALMEN1KMT2A | |
| SCHEMBL4637351 | 0.89 | CCR5 (0.38) | ITGB2ICAM1ITGALMEN1KMT2A | |
| SCHEMBL4637461 | 0.88 | MCHR1 (0.36) | MCHR1CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4639084 | 0.88 | MCHR1 (0.36) | MCHR1CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4637464 | 0.88 | MCHR1 (0.36) | MCHR1CYP3A4CYP2C19ALDH1A1MAPK1 | |
| SCHEMBL4637446 | 0.85 | MCHR1 (0.37) | MCHR1TRPV4ITGB2ICAM1ITGAL | |
| SCHEMBL4638978 | 0.85 | MCHR1 (0.37) | MCHR1TRPV4ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | BAUMANN KARL | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262070-A1 | Pharmaceutically Active Tetrahydro-Pyrrolizinone Compounds | VCAM1, ICAM1, EPCAM | MCHR1 2526/4885CYP3A4 1012/4885CYP2C19 1229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.