Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.72 |
| ▸ | MEN1 | O00255 | 6/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | GMNN | O75496 | 1/20 | 0.66 |
| ▸ | TTR | P02766 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132692 | 0.89 | NPC1 (0.58) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL4686279 | 0.88 | DHODH (0.76) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5255345 | 0.87 | LMNA (0.71) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7271426 | 0.85 | MEN1 (0.58) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6324644 | 0.84 | DHODH (0.72) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL9469395 | 0.84 | DHODH (1.00) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL479877 | 0.83 | DHODH (1.00) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL10144303 | 0.83 | MEN1 (0.71) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL15636690 | 0.83 | LMNA (0.78) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12478330 | 0.82 | DHODH (0.71) | DHODHMEN1KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574053-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | FERRING B.V. | 2008-10-16 | — | — | US | disclosed |
| US-7335677-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING B.V. (NL) | 2008-02-26 | — | — | US | disclosed |
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | FERRING B. V. | 2005-02-24 | — | — | US | disclosed |
| EP-1446116-A1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING B.V. (NL) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003035057-A1 | INHIBITORS OF DIPEPTIDYL PEPTIDASE IV | FERRING B.V. (NL) | 2003-05-01 | — | — | WO | disclosed |
| CN-1040327-C | Optionally substituted pyrido [2,3-d] pyrimidine-2,4(1H,3H)-diones and pyrido [2,3-d] pyrimidine-2(1H,3H)-ones | SYNTEX INC (US) | 1998-10-21 | — | — | CN | disclosed |
| US-5439916-A | Antiallergens,-inflammatory and -ulcer agents; hypotensive agents; immunosuppressants; skin disorders | SCHERING CORPORATION (US) | 1995-08-08 | — | — | US | disclosed |
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |
| US-5126352-A | Antiallergy, antiinflammatory, antiulcer, hypotensive, antibody inhibitors | SCHERING CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5116840-A | Antiulcer, antiinflammatory, hypotensive, immunosuppressants | SCHERING CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0229823-B1 | POLYCYCLIC QUINOLINE, NAPHTHYRIDINE AND PYRAZINOPYRIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4988705-A | Antiallergens and -inflammatory agents; hypotensive agents immunological suppression; hyperproliferative skin disorders such as psoriasis | SCHERING CORPORATION (US) | 1991-01-29 | — | — | US | disclosed |
| US-4810708-A | ANTIALLERGY, IMMUNOSUPPRESSIVE | SCHERING CORPORATION (US) | 1989-03-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043299-A1 | Inhibitors of dipeptidyl peptidase iv | DPP4, DPP9, DPP3 | DHODH 2270/4885MEN1 3528/4885KMT2A 3490/4885 |
| US-20080255126-A1 | Inhibitors of post-proline cleaving proteases | PREP, PEPD, DPP4 | DHODH 2709/4885MEN1 3322/4885KMT2A 3682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.