Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.63 |
| ▸ | AHR | P35869 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 3/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905983 | 0.87 | DHODH (0.72) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL9132692 | 0.87 | NPC1 (0.58) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL28282946 | 0.84 | LMNA (0.73) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL28824933 | 0.84 | RAB9A (0.76) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL29898323 | 0.84 | RAB9A (0.76) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL7271426 | 0.84 | MEN1 (0.58) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL28949487 | 0.83 | LMNA (0.71) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL5083062 | 0.83 | RAB9A (0.72) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL29898238 | 0.83 | LMNA (0.71) | LMNARAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL9496511 | 0.83 | LMNA (1.00) | LMNARAB9ANPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574053-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| EP-0631580-A1 | PYRIDO 2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5264437-A | Antiinflammatory agents, immunosuppressants or antiallergens | SYNTEX (U.S.A.) INC. (US) | 1993-11-23 | — | — | US | disclosed |
| WO-1993019068-A1 | PYRIDO[2,3-d]PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1993-09-30 | — | — | WO | disclosed |