Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.48 |
| ▸ | LIPE | Q05469 | 4/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906341 | 0.90 | LMNA (0.47) | LMNASCN9ALIPETHRBMAPT | |
| SCHEMBL4899851 | 0.83 | LMNA (0.47) | LMNASCN9ALIPEMAPTMAPK1 | |
| SCHEMBL968444 | 0.83 | NPC1 (0.49) | MAPT | |
| SCHEMBL1437058 | 0.79 | MAPT (0.40) | MAPTNPSR1 | |
| SCHEMBL876080 | 0.78 | LIPE (0.57) | LMNASCN9ALIPETHRBMAPT | |
| SCHEMBL3375358 | 0.77 | PPARA (0.52) | LMNAMAPT | |
| SCHEMBL4902365 | 0.77 | IDO1 (0.42) | LMNASCN9ALIPEMAPTBRD4 | |
| SCHEMBL4466375 | 0.76 | NPC1 (0.47) | MAPT | |
| SCHEMBL3368282 | 0.74 | MAPT (0.46) | MAPTNPSR1RAB9A | |
| SCHEMBL3374108 | 0.74 | PPARG (0.49) | LMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | LMNA 319/4885SCN9A 4504/4885LIPE 130/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | LMNA 319/4885SCN9A 4504/4885LIPE 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.