Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4905476 | 0.90 | ALDH1A1 (0.40) | ALDH1A1PKMTRPM8MEN1KMT2A | |
| SCHEMBL4900555 | 0.90 | ALDH1A1 (0.41) | ALDH1A1PKMTRPM8MEN1KMT2A | |
| SCHEMBL4899866 | 0.85 | LMNA (0.40) | ALDH1A1MEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL4899491 | 0.84 | KMT2A (0.53) | ALDH1A1TRPM8MEN1KMT2AL3MBTL1 | |
| SCHEMBL4898233 | 0.82 | ALDH1A1 (0.41) | ALDH1A1PKMMEN1KMT2AL3MBTL1 | |
| SCHEMBL4906844 | 0.80 | POLB (0.41) | LMNAPOLBPTGDR2 | |
| SCHEMBL4907293 | 0.78 | LMNA (0.39) | ALDH1A1TRPM8L3MBTL1LMNAPOLB | |
| SCHEMBL4908224 | 0.77 | HCRTR2 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1LMNA | |
| SCHEMBL4906535 | 0.76 | ALDH1A1 (0.51) | ALDH1A1PKMMEN1KMT2AL3MBTL1 | |
| SCHEMBL4894579 | 0.75 | NPC1 (0.41) | ALDH1A1PKMMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | ALDH1A1 2956/4885PKM 861/4885TRPM8 4317/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | ALDH1A1 2956/4885PKM 861/4885TRPM8 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.