Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 6/20 | 0.48 |
| ▸ | MAOB | P27338 | 6/20 | 0.48 |
| ▸ | TLR4 | O00206 | 6/20 | 0.48 |
| ▸ | TLR2 | O60603 | 6/20 | 0.48 |
| ▸ | FBP1 | P09467 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906872 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPSR1MAOAMAOBTLR4 | |
| SCHEMBL4909005 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2NPSR1KDM4ERAB9AALDH1A1 | |
| SCHEMBL566004 | 0.75 | MAOB (0.80) | MAOAMAOBTLR4TLR2FBP1 | |
| SCHEMBL566003 | 0.75 | MAOB (0.80) | MAOAMAOBTLR4TLR2FBP1 | |
| SCHEMBL15380599 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2NPSR1KDM4ERAB9AALDH1A1 | |
| SCHEMBL19973124 | 0.73 | MAPT (0.50) | SMN1; SMN2NPSR1MAOBRAB9AALDH1A1 | |
| SCHEMBL236393 | 0.73 | MAOA (0.72) | SMN1; SMN2NPSR1MAOAMAOBTLR4 | |
| SCHEMBL21483129 | 0.73 | TLR4 (0.65) | MAOAMAOBTLR4TLR2FBP1 | |
| SCHEMBL236394 | 0.73 | MAOA (0.72) | SMN1; SMN2NPSR1MAOAMAOBTLR4 | |
| SCHEMBL15475131 | 0.73 | HPGD (0.43) | SMN1; SMN2NPSR1KDM4ERAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PFIZER INC. | 2008-04-17 | — | — | US | disclosed |
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | HAMANAKA ERNEST S | 2006-10-12 | — | — | US | disclosed |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060229363-A1 | Substituted Heteroaryl- and Phenylsulfamoyl Compounds | PPARA, PPARG, PPARD | SMN1; SMN2 3271/4885NPSR1 773/4885MAOA 4248/4885 |
| US-20050288340-A1 | Substituted heteroaryl- and phenylsulfamoyl compounds | PPARA, PPARG, PPARD | SMN1; SMN2 3404/4885NPSR1 735/4885MAOA 4248/4885 |
| US-20080090829-A1 | SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS | PPARA, PPARG, PPARD | SMN1; SMN2 3404/4885NPSR1 735/4885MAOA 4248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.