Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.63 |
| ▸ | PDE4A | P27815 | 13/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5076138 | 0.92 | BRAF (0.53) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281530 | 0.92 | BRAF (0.53) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4915965 | 0.90 | BRAF (0.57) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908489 | 0.90 | BRAF (0.79) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281346 | 0.84 | BRAF (0.78) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907574 | 0.84 | BRAF (0.77) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281537 | 0.82 | ALDH1A1 (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281710 | 0.82 | BRAF (0.68) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907064 | 0.80 | BRAF (0.52) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4903000 | 0.78 | BRAF (0.84) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | MCKENNA JEFFREY M | 2008-01-03 | — | — | US | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004271-A1 | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith | PDE4A, PDE4B, BRAF | BRAF 3/4885PDE4A 1/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.