Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.53 |
| ▸ | PDE4A | P27815 | 8/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14281530 | 0.92 | BRAF (0.53) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4906952 | 0.92 | BRAF (0.63) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281537 | 0.84 | ALDH1A1 (0.49) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4915965 | 0.84 | BRAF (0.57) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281710 | 0.82 | BRAF (0.68) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4908489 | 0.82 | BRAF (0.79) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907064 | 0.80 | BRAF (0.52) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281364 | 0.77 | BRAF (0.63) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14281713 | 0.77 | BRAF (0.66) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4907574 | 0.77 | BRAF (0.77) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984377-A2 | INHIBITORS OF TNF ALPHA , PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | Signal Pharmaceuticals LLC (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007084560-A2 | INHIBITORS OF TNFα, PDE4 AND B-RAF, COMPOSITIONS THEREOF AND METHODS OF USE THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-07-26 | — | — | WO | disclosed |