Sugi Predict

Sugi Predict / Compounds / SCHEMBL4907291

SCHEMBL4907291

SCHEMBL4907291

Cc1ccc(S(=O)(=O)NCCSc2ncccc2C(F)(F)F)cc1C(=O)O

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.50
▸ ALDH1A1 P00352 7/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ POLB P06746 2/20 0.42
▸ L3MBTL1 Q9Y468 2/20 0.42
▸ HTT P42858 2/20 0.41
▸ TSHR P16473 2/20 0.41
▸ USP2 O75604 1/20 0.41
▸ IDH2 P48735 1/20 0.40
▸ RAB9A P51151 2/20 0.39
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ DHODH Q02127 1/20 0.39
▸ HDAC6 Q9UBN7 1/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ PKM P14618 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.37
▸ NPC1 O15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4899948 0.92 LMNA (0.40) LMNAALDH1A1MAPTPOLBL3MBTL1
SCHEMBL4903694 0.90 ALDH1A1 (0.40) LMNAALDH1A1MAPTL3MBTL1HTT
SCHEMBL4904076 0.83 ALDH1A1 (0.39) LMNAALDH1A1MAPTPOLBL3MBTL1
SCHEMBL4899482 0.80 KMT2A (0.52) LMNAALDH1A1KDM4EMAPTPOLB
SCHEMBL4899856 0.78 LMNA (0.53) LMNAALDH1A1KDM4EMAPTPOLB
SCHEMBL4906535 0.78 ALDH1A1 (0.51) LMNAALDH1A1KDM4EMAPTPOLB
SCHEMBL4907293 0.76 LMNA (0.39) LMNAALDH1A1KDM4EPOLBL3MBTL1
SCHEMBL4900628 0.75 LMNA (0.51) LMNAALDH1A1KDM4EMAPTPOLB
SCHEMBL4906838 0.74 LMNA (0.48) LMNAALDH1A1KDM4EMAPTPOLB
SCHEMBL4908216 0.73 LMNA (0.54) LMNAALDH1A1KDM4EMAPTPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885ALDH1A1 2664/4885KDM4E 3750/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885KDM4E 3834/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885KDM4E 3834/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.