Sugi Predict

Sugi Predict / Compounds / SCHEMBL4907405

SCHEMBL4907405

SCHEMBL4907405

Cc1cc(S(=O)(=O)NCCc2coc(-c3ccc(C(C)(C)C)cc3)n2)cc(C(=O)O)c1C

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 8/20 0.39
▸ LMNA P02545 4/20 0.39
▸ SMN1; SMN2 Q16637 3/20 0.39
▸ HTT P42858 2/20 0.39
▸ PPARG P37231 1/20 0.36
▸ PPARA Q07869 1/20 0.36
▸ KDM4E B2RXH2 4/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ HPGD P15428 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ MAPT P10636 2/20 0.35
▸ PTPN5 P54829 1/20 0.35
▸ NR1H4 Q96RI1 2/20 0.34
▸ POLB P06746 2/20 0.33
▸ KLK1 P06870 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4895720 0.92 PPARG (0.40) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4911898 0.92 PPARG (0.44) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4897574 0.90 LMNA (0.47) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4899812 0.85 PPARG (0.43) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4900708 0.85 PPARG (0.41) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4903863 0.84 PPARG (0.42) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4895920 0.84 LMNA (0.41) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4897418 0.84 PPARA (0.47) ALDH1A1LMNASMN1; SMN2HTTPPARG
SCHEMBL4906047 0.83 LMNA (0.52) ALDH1A1LMNASMN1; SMN2HTTKDM4E
SCHEMBL4906505 0.82 LMNA (0.46) ALDH1A1LMNASMN1; SMN2HTTPPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD ALDH1A1 2664/4885LMNA 317/4885SMN1; SMN2 3271/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD ALDH1A1 2956/4885LMNA 319/4885SMN1; SMN2 3404/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD ALDH1A1 2956/4885LMNA 319/4885SMN1; SMN2 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.