Sugi Predict

Sugi Predict / Compounds / SCHEMBL4895920

SCHEMBL4895920

SCHEMBL4895920

CC(C)c1ccc(S(=O)(=O)NCCc2coc(-c3ccc(C(C)(C)C)cc3)n2)cc1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 6/20 0.41
▸ ALDH1A1 P00352 5/20 0.39
▸ SMN1; SMN2 Q16637 3/20 0.39
▸ HTT P42858 2/20 0.39
▸ MAPT P10636 2/20 0.39
▸ TP53 P04637 1/20 0.39
▸ KDM4E B2RXH2 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ HPGD P15428 1/20 0.38
▸ RAB9A P51151 1/20 0.36
▸ POLB P06746 2/20 0.36
▸ HTR6 P50406 1/20 0.36
▸ PTPN5 P54829 1/20 0.36
▸ AKR1C3 P42330 2/20 0.35
▸ PPARG P37231 1/20 0.35
▸ PPARA Q07869 1/20 0.35
▸ NPSR1 Q6W5P4 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ BCL2 P10415 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4902454 0.92 LMNA (0.38) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4897574 0.88 LMNA (0.47) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4899812 0.88 PPARG (0.43) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4907405 0.84 ALDH1A1 (0.39) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4900708 0.83 PPARG (0.41) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4906000 0.82 PPARG (0.41) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4906505 0.80 LMNA (0.46) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4900873 0.80 PPARG (0.52) LMNAALDH1A1SMN1; SMN2HTTKDM4E
SCHEMBL4906194 0.79 MAPT (0.42) LMNAALDH1A1SMN1; SMN2HTTMAPT
SCHEMBL4895720 0.78 PPARG (0.40) LMNAALDH1A1SMN1; SMN2HTTMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PFIZER INC. 2008-04-17 — — US disclosed
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds HAMANAKA ERNEST S 2006-10-12 — — US disclosed
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PFIZER INC 2005-12-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060229363-A1 Substituted Heteroaryl- and Phenylsulfamoyl Compounds PPARA, PPARG, PPARD LMNA 317/4885ALDH1A1 2664/4885SMN1; SMN2 3271/4885
US-20050288340-A1 Substituted heteroaryl- and phenylsulfamoyl compounds PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885SMN1; SMN2 3404/4885
US-20080090829-A1 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS PPARA, PPARG, PPARD LMNA 319/4885ALDH1A1 2956/4885SMN1; SMN2 3404/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.