Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909502 | 0.89 | CACNA1H (0.45) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL4908857 | 0.81 | L3MBTL1 (0.41) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL2173761 | 0.81 | CACNA1H (0.45) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL4912266 | 0.80 | CACNA1H (0.44) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL18775082 | 0.78 | L3MBTL1 (0.41) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL24739273 | 0.77 | L3MBTL1 (0.44) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL15125242 | 0.77 | L3MBTL1 (0.41) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E | |
| SCHEMBL1927572 | 0.77 | HDAC1 (0.45) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4A | |
| SCHEMBL18329395 | 0.75 | CACNA1H (0.51) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4A | |
| SCHEMBL15244395 | 0.75 | CACNA1B (0.56) | CACNA1HCACNA1BCACNA1CL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051578-A1 | SUBSTITUTED BIARYLS, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | DAHMANN GEORG | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051578-A1 | SUBSTITUTED BIARYLS, PROCESS FOR THEIR MANUFACTURE AND USE THEREOF AS MEDICAMENTS | CYP11B2, CYP3A43, CYP11B1 | CACNA1H 2827/4885CACNA1B 3076/4885CACNA1C 3304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.