Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.95 |
| ▸ | ACHE | P22303 | 6/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.95 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.95 |
| ▸ | HPGD | P15428 | 3/20 | 0.95 |
| ▸ | GLA | P06280 | 2/20 | 0.95 |
| ▸ | CASP1 | P29466 | 2/20 | 0.95 |
| ▸ | CASP7 | P55210 | 2/20 | 0.95 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.95 |
| ▸ | MAOA | P21397 | 2/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.95 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.95 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.95 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.95 |
| ▸ | NQO2 | P16083 | 1/20 | 0.95 |
| ▸ | DRD1 | P21728 | 1/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminacrine SCHEMBL14999 | 0.97 | HSD17B10 (1.00) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL29354393 | 0.97 | HSD17B10 (1.00) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL30355377 | 0.95 | HSD17B10 (0.95) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL14482032 | 0.95 | HSD17B10 (0.95) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL4344206 | 0.95 | HSD17B10 (0.95) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL635597 | 0.95 | RAB9A (1.00) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL31237441 | 0.95 | RAB9A (1.00) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL18989123 | 0.95 | HSD17B10 (0.95) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL635598 | 0.95 | RAB9A (1.00) | HSD17B10ACHEALDH1A1KDM4EHPGD | |
| Aminacrine SCHEMBL28190415 | 0.95 | HSD17B10 (0.95) | HSD17B10ACHEALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193687-B2 | Phenyl N-mustard linked to DNA-affinic molecules or water-soluble aryl rings, method and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2015-11-24 | — | — | US | disclosed |
| US-20130178494-A1 | PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS | ACADEMIA SINICA (TW) | 2013-07-11 | — | — | US | disclosed |
| US-8222297-B2 | e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma | ACADEMIA SINICA (TW) | 2012-07-17 | — | — | US | disclosed |
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | WEE1, PCNA, ATIC | HSD17B10 3037/4885ACHE 1385/4885ALDH1A1 1144/4885 |
| US-20130178494-A1 | PHENYL N-MUSTARD LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE ARYL RINGS, METHOD AND THEIR USE AS CANCER THERAPEUTIC AGENTS | PCNA, WEE1, UNG | HSD17B10 4815/4885ACHE 4494/4885ALDH1A1 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.