Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 7/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.36 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.36 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 2/20 | 0.34 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | POLR1A | O95602 | 1/20 | 0.31 |
| ▸ | ECE1 | P42892 | 1/20 | 0.31 |
| ▸ | MUS81 | Q96NY9 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4906231 | 0.93 | RAD52 (0.40) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4913012 | 0.89 | TOP2A (0.41) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4911335 | 0.88 | RAD52 (0.42) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4907584 | 0.88 | TOP2A (0.34) | TOP2ATOP2BMTNR1AMTNR1BTP53 | |
| SCHEMBL4911394 | 0.87 | RAD52 (0.46) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4910432 | 0.86 | TOP2A (0.45) | RAD52TOP2ATOP2BTP53MAPT | |
| SCHEMBL6792752 | 0.83 | AOX1 (0.44) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4906249 | 0.82 | RAD52 (0.41) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4913169 | 0.82 | RAD52 (0.41) | RAD52AOX1UHRF1SMARCA2MOK | |
| SCHEMBL4903077 | 0.82 | RAD52 (0.47) | RAD52AOX1UHRF1SMARCA2MOK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2008-07-17 | — | — | US | claimed |
| US-8222297-B2 | e.g. 1-[3-(acridin-9-ylamino)-5-hydroxymethylphenyl]-3-{4-[bis(2-chloroethyl)amino]phenyl}urea; anticarcinogenic agent; improved chemical stability and efficacy; brain tumor, breast cancer, colon cancer, leukemia, and neuroblastoma | ACADEMIA SINICA (TW) | 2012-07-17 | — | — | US | disclosed |
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | ACADEMIA SINICA (TW) | 2008-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171765-A1 | Aniline or phenol mustards linked to DNA-affinic molecules or water-soluble aromatic rings and their use as cancer therapeutic agents | WEE1, PCNA, ATIC | RAD52 717/4885AOX1 801/4885UHRF1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.