Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9490115 | 0.84 | HSP90AA1 (0.71) | NPC1RAB9AALDH1A1HSP90AA1HPGD | |
| SCHEMBL29446998 | 0.83 | CYP1A2 (0.50) | ALDH1A1MAPK1 | |
| SCHEMBL1193202 | 0.83 | NPC1 (0.62) | NPC1RAB9AHPGDKMT2ASMN1; SMN2 | |
| SCHEMBL4914982 | 0.81 | L3MBTL1 (0.66) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL970780 | 0.81 | NPC1 (0.62) | NPC1RAB9AALDH1A1HSP90AA1HPGD | |
| SCHEMBL6975152 | 0.81 | DRD2 (0.65) | NPC1RAB9ASMN1; SMN2DRD2DRD3 | |
| SCHEMBL4768144 | 0.79 | HDAC3 (0.71) | NPC1RAB9AALDH1A1HSP90AA1HPGD | |
| SCHEMBL3030903 | 0.79 | HSP90AA1 (0.69) | NPC1RAB9AALDH1A1HSP90AA1HPGD | |
| SCHEMBL4912134 | 0.79 | POLB (0.66) | NPC1RAB9AALDH1A1HSP90AA1HPGD | |
| SCHEMBL3034137 | 0.79 | HSP90AA1 (0.65) | NPC1RAB9AALDH1A1HSP90AA1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275028-A1 | Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof | SIENA BIOTECH S.P.A. (IT) | 2008-11-06 | — | — | US | disclosed |
| CN-101018774-A | Modulators of alpha7 nicotinic acetylcholine receptors and therapeutic uses thereof | SIENA BIOTECH SPA (IT) | 2007-08-15 | — | — | CN | disclosed |
| EP-1778658-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006008133-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2006-01-26 | — | — | WO | disclosed |
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |
| US-5726208-A | Heterocyclic tertiary amines | ADIR ET COMPAGNIE (FR) | 1998-03-10 | — | — | US | disclosed |
| EP-0768307-A1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-04-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275028-A1 | Modulators or Alpha7 Nicotinic Acetylcholine Receptors and Therapeutic Uses Thereof | CHRNA7, CHRNA5, CHRNA1 | NPC1 2055/4885RAB9A 1400/4885ALDH1A1 2091/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.