Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.71 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.71 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.66 |
| ▸ | CSNK2A2 | P19784 | 4/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 4/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902721 | 0.83 | SHMT2 (0.77) | MKNK2MKNK1SHMT2CSNK2A2CSNK2B | |
| SCHEMBL4907228 | 0.80 | PIP4K2C (0.60) | MKNK2CSNK2A2CSNK2BCSNK2A1MAPK1 | |
| SCHEMBL14184168 | 0.80 | MEN1 (0.59) | MKNK2MKNK1SHMT2MAPTHTT | |
| SCHEMBL14184165 | 0.79 | MEN1 (0.66) | MKNK2MKNK1MAPTHTTAURKB | |
| SCHEMBL23494178 | 0.76 | MKNK2 (0.67) | MKNK2MKNK1SHMT2CSNK2A2CSNK2B | |
| SCHEMBL17079920 | 0.76 | CSNK2A2 (0.79) | MKNK2MKNK1SHMT2CSNK2A2CSNK2B | |
| SCHEMBL26786625 | 0.74 | AURKB (0.63) | MAPTAURKBEGFRAURKASMN1; SMN2 | |
| SCHEMBL13164963 | 0.72 | MAPK1 (1.00) | MKNK2MKNK1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL17079910 | 0.71 | FGFR1 (0.72) | MKNK2MKNK1SHMT2CSNK2A2CSNK2B | |
| SCHEMBL2369092 | 0.71 | MKNK2 (0.84) | MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080108611-A1 | SUBSTITUTED THIENOPYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-05-08 | — | — | US | claimed |
| WO-2007084815-A2 | SUBSTITUTED THIENOPYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-26 | — | — | WO | claimed |
| WO-2007084815-A2 | SUBSTITUTED THIENOPYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108611-A1 | SUBSTITUTED THIENOPYRIMIDINE KINASE INHIBITORS | MAP4K2, MAP3K6, MAP3K2 | MKNK2 74/4885MKNK1 77/4885SHMT2 857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.