Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 16/20 | 0.42 |
| ▸ | APOB | P04114 | 1/20 | 0.36 |
| ▸ | MTTP | P55157 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782858 | 0.85 | KDM4E (0.44) | NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL4782869 | 0.85 | KDM4E (0.44) | NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL4781555 | 0.80 | NR1H2 (0.40) | NR1H2APOBMTTP | |
| SCHEMBL4851567 | 0.78 | NR1H2 (0.43) | NR1H2APOBMTTPNR1H3MEN1 | |
| SCHEMBL4782289 | 0.76 | NR1H2 (0.51) | NR1H2APOBMTTP | |
| SCHEMBL4782285 | 0.76 | NR1H2 (0.51) | NR1H2APOBMTTP | |
| SCHEMBL4782325 | 0.75 | NR1H2 (0.48) | NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL4907973 | 0.75 | NR1H2 (0.46) | NR1H2NR1H3 | |
| SCHEMBL4782323 | 0.74 | NR1H2 (0.47) | NR1H2NR1H3MEN1KMT2A | |
| SCHEMBL4911955 | 0.73 | KDM4E (0.43) | NR1H2APOBMTTPNR1H3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061006-A1 | SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |