Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806456 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL9804546 | 0.81 | NMT1 (0.48) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL4918574 | 0.81 | KDM4E (0.54) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL17331499 | 0.79 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL343728 | 0.78 | PSEN1 (0.46) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL17331785 | 0.75 | KDM4E (0.53) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL17339104 | 0.75 | KDM4E (0.52) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL17331394 | 0.74 | IDO1 (0.51) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL4967007 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL8325573 | 0.74 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1MAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | SCHWARZ PHARMA AG (DE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051409-A1 | Indolizine Carboxamides and Aza and Diaza Derivatives Thereof | GRIN2A, GRIN2C, GRIN1 | SMN1; SMN2 3676/4885ALDH1A1 459/4885MAPK1 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.