Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Thiethylperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 5/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 5/20 | 1.00 |
| ▸ | HTR2A | P28223 | 5/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 5/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 5/20 | 1.00 |
| ▸ | HRH1 | P35367 | 5/20 | 1.00 |
| ▸ | DRD3 | P35462 | 5/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | DRD1 | P21728 | 4/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 4/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 1.00 |
| ▸ | MC3R | P41968 | 3/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiethylperazine SCHEMBL29507072 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL29688372 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL29430925 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL30903918 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL41678 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL17079861 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL10624613 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL41676 | 0.91 | HRH1 (0.83) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL41677 | 0.90 | ADRA2A (0.80) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Thiethylperazine SCHEMBL13724994 | 0.90 | SLC6A2 (0.80) | HTR1AADRA2ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6384 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4714452-A1 | METHODS FOR TREATING SARS COV-2 INFECTIONS | Gilead Sciences, Inc. (US) | 2026-03-25 | — | — | EP | claimed |
| WO-2025082959-A1 | A PHENOTHIAZINE-RELATED COMPOUND CONJUGATED TO A PEPTIDE | UNIVERSITY OF ULSTER (GB) | 2025-04-24 | — | — | WO | claimed |
| US-20250082647-A1 | SPECIFIC DOSAGE OF PHENOTHIAZINE COMPOUNDS FOR USE IN TREATMENT OR PREVENTION OF ALZHEIMER'S DEMENTIA | IMMUNGENETICS AG (DE) | 2025-03-13 | — | — | US | claimed |
| US-20240382562-A1 | METHODS AND COMPOSITIONS FOR INDUCING DIFFERENTIATION OF HUMAN BROWN ADIPOCYTE PROGENITORS | ENERGESIS PHARMACEUTICALS, INC. | 2024-11-21 | — | — | US | claimed |
| US-20240366639-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO INC (US) | 2024-11-07 | — | — | US | claimed |
| WO-2024220459-A2 | COMBINATION THERAPY WITH LP-PLA2 INHIBITOR AND A SECOND AGENT | SCINEURO THERAPEUTICS INC. (US) | 2024-10-24 | — | — | WO | claimed |
| WO-2024191125-A1 | METHOD FOR ACTIVATING ENDOGENOUS NEURAL STEM CELLS THROUGH LOW-INTENSITY FOCUSED ULTRASOUND TREATMENT | 연세대학교 산학협력단 | 2024-09-19 | — | — | WO | claimed |
| EP-3863708-B1 | MIXED IONIC CONDUCTORS AND CORRESPONDING DEVICES, SYSTEMS AND METHODS OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2024-09-11 | — | — | EP | claimed |
| WO-2024083822-A1 | IDENTIFYING A SUBJECT SUFFERING FROM ALZHEIMER'S DEMENTIA OR BEING AT RISK OF DEVELOPING ALZHEIMER'S DEMENTIA | IMMUNGENETICS AG (DE) | 2024-04-25 | — | — | WO | claimed |
| WO-2023055939-A9 | APPARATUS, SYSTEMS AND METHODS FOR TRANSDERMAL DRUG DELIVERY, PERMEABILITY ENHANCEMENT AND AUGMENTATION | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2024-04-25 | — | — | WO | claimed |
| WO-2001034232-A1 | INHALATION NEBULIZER | Pari GmbH Spezialisten für effektive Inhalation (DE) | 2001-05-17 | — | — | WO | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| WO-2000045813-A1 | METHOD FOR ENHANCEMENT OF DELIVERY OF THC BY THE ADMINISTRATION OF ITS PRODRUGS VIA THE NASAL ROUTE | NEW MILLENNIUM PHARMACEUTICAL RESEARCH, INC. (US) | 2000-08-10 | — | — | WO | claimed |
| WO-2000035457-A1 | USE OF APOMORPHINE IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ORGANIC ERECTILE DYSFUNCTION IN MALES | ABBOTT LABORATORIES (US) | 2000-06-22 | — | — | WO | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| EP-0784474-A2 | PARENTERAL PHARMACEUTICAL COMPOSITIONS CONTAINING GF120918A | GLAXO WELLCOME INC. (US) | 1997-07-23 | — | — | EP | claimed |
| WO-1996011007-A1 | PARENTERAL PHARMACEUTICAL COMPOSITIONS CONTAINING GF120918A | GLAXO WELLCOME INC. (US) | 1996-04-18 | — | — | WO | claimed |
| US-5023073-A | Method of combating flupropadine poisoning using phenothiazines | BURROUGHS WELLCOME CO. (US) | 1991-06-11 | — | — | US | claimed |
| US-4235236-A | Device for dispensing drug by combined diffusional and osmotic operations | ALZA CORPORATION (US) | 1980-11-25 | — | — | US | claimed |