SCHEMBL491263

SCHEMBL491263

C=C(C(=O)O)C(=O)c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 8/20 0.62
CES1 P23141 7/20 0.62
MAPT P10636 5/20 0.55
ALDH1A1 P00352 4/20 0.55
LMNA P02545 3/20 0.54
NPSR1 Q6W5P4 2/20 0.54
SMN1; SMN2 Q16637 2/20 0.54
XBP1 P17861 1/20 0.54
ATM Q13315 1/20 0.54
POLB P06746 2/20 0.50
USP2 O75604 1/20 0.50
MAPK1 P28482 1/20 0.50
HTT P42858 1/20 0.50
EGFR P00533 2/20 0.48
TSHR P16473 2/20 0.48
DAO P14920 1/20 0.48
NAPRT Q6XQN6 1/20 0.48
AKT1 P31749 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
HPGD P15428 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8120050 0.98 CES2 (0.59) CES2CES1MAPTALDH1A1LMNA
SCHEMBL4826427 0.90 CES2 (0.68) CES2CES1MAPTALDH1A1LMNA
Bromide SCHEMBL9419968 0.87 CES2 (0.65) CES2CES1MAPTALDH1A1LMNA
SCHEMBL27671273 0.86 CES2 (0.46) CES2CES1MAPTALDH1A1LMNA
Nonane SCHEMBL11560700 0.84 CES2 (0.62) CES2CES1MAPTALDH1A1LMNA
Benzil SCHEMBL27564092 0.82 CES2 (0.74) CES2CES1MAPTALDH1A1LMNA
SCHEMBL28800035 0.82 PARP10 (0.56) CES2CES1ALDH1A1SMN1; SMN2POLB
SCHEMBL2302999 0.81 CPT1B (0.67) CES2CES1MAPTALDH1A1LMNA
SCHEMBL3101206 0.81 CES2 (0.56) CES2CES1MAPTALDH1A1LMNA
SCHEMBL14886367 0.81 CES2 (0.67) CES2CES1MAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 241 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113185529-B Preparation method of benzoyl-containing acrylic acid podophyllotoxin ester derivative and application of benzoyl-containing acrylic acid podophyllotoxin ester derivative in tumor inhibition 济宁市第一人民医院 2022-06-21 CN claimed
CN-113185529-A Preparation method of benzoyl-containing acrylic acid podophyllotoxin ester derivative and application of benzoyl-containing acrylic acid podophyllotoxin ester derivative in tumor inhibition 济宁市第一人民医院 2021-07-30 CN claimed
EP-1363869-B1 PROCESS FOR THE PREPARATION OF ALKYL BENZOYLACRYLATES WEYLCHEM LAMOTTE (FR) 2015-04-08 EP claimed
CN-102816067-A 4-hydroxybenzoylacrylic acid derivative, preparation method thereof and application INST MEDICINAL BIOTECHNOLOGY 2012-12-12 CN claimed
CN-102171613-A Ultraviolet light absorbing ketones of 2- (2-hydroxyphenyl) benzotriazole CHIA-HU CHANG 2011-08-31 CN claimed
EP-0903337-B1 PROCESS FOR THE PREPARATION OF 1-ALKOXYCARBONYL-3-PHENYLPROPYL DERIVATIVES KANEKA CORP (JP) 2006-04-12 EP claimed
EP-1132375-B1 AMINOACRYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME ASAHI GLASS CO LTD (JP) 2003-07-16 EP claimed
EP-1132375-A1 AMINOACRYLIC ACID DERIVATIVES AND PROCESS FOR PRODUCING THE SAME ASAHI GLASS COMPANY LTD. (JP) 2001-09-12 EP claimed
US-6118010-A CATALYTIC REDUCTION OF THE 1-ALKOXYCARBONYL-3-OXO-3-PHENYLPROPYL DERIVATIVE KANEKA CORPORATION (JP) 2000-09-12 US claimed
EP-0903337-A1 PROCESS FOR THE PREPARATION OF 1-ALKOXYCARBONYL-3-PHENYLPROPYL DERIVATIVES KANEKA CORPORATION (JP) 1999-03-24 EP claimed
EP-0239062-B1 N2-(1-CARBOXY-3-OXO-3-PHENYLPROPYL)-L-LYSINE COMPOUNDS AND THEIR DERIVATIVES KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1991-05-29 EP claimed
EP-0135838-B1 3-PHENYL-4-METHOXYCARBONYL PYRAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AGAINST PLANT GROWTH BASF Aktiengesellschaft (DE) 1990-04-18 EP claimed
EP-0190687-B1 PROCESS FOR PREPARING ETHYL-ALPHA-(1-CARBOXYETHYL)-AMINO-GAMMA-OXO-GAMMA-PHENYLBUTYRATE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-10-05 EP claimed
CN-88100318-A The preparation of quinolone carboxylic acid and intermediate thereof 1988-08-03 CN claimed
EP-0275971-A1 Process and intermediates for quinolonecaboxylic acid KYORIN PHARMACEUTICAL CO., LTD. (JP) 1988-07-27 EP claimed
EP-0239062-A2 N2-(1-carboxy-3-oxo-3-phenylpropyl)-L-Lysine compounds and their derivatives KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1987-09-30 EP claimed
EP-0052330-B1 NOVEL RESIN COMPOSITION, COATING MATERIAL COMPRISING SAID RESIN COMPOSITION AND METHOD FOR FORMING COATINGS Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1984-09-05 EP claimed
US-4165877-A POLYBUTADIENE CROSSLINKED WITH A POLYVALENT METAL SALT OF AN UNSATURATED ACID PRINCETON CHEMICAL RESEARCH, INC. (US) 1979-08-28 US claimed
US-4065537-A EXTRUDING AND CUTTING A CROSSLINKABLE ELASTOMER PRINCETON CHEMICAL RESEARCH, INC. (US) 1977-12-27 US claimed
US-4056269-A POLYBUTADIENE PRINCETON CHEMICAL RESEARCH, INC. (US) 1977-11-01 US claimed