Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.73 |
| ▸ | FERMT2 | Q96AC1 | 2/20 | 0.65 |
| ▸ | NCF1 | P14598 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALPG | P10696 | 1/20 | 0.58 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RAD52 | P43351 | 1/20 | 0.55 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ACP1 | P24666 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15191325 | 0.91 | HTR1A (0.72) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL15483263 | 0.91 | HTR1A (0.73) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL4142709 | 0.82 | HTR1A (0.80) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL8909254 | 0.82 | HTR1A (0.80) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL30102645 | 0.82 | FERMT2 (0.53) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL15191596 | 0.81 | CYP2C19 (0.49) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL18631820 | 0.81 | HTR1A (0.83) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL18290254 | 0.80 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL9850466 | 0.80 | HTR1A (0.89) | HTR1AADRA1DADRA1AADRA1BFERMT2 | |
| SCHEMBL22390094 | 0.80 | HTR1A (1.00) | HTR1AADRA1DADRA1AADRA1BFERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2008-02-21 | — | — | US | disclosed |
| US-6992089-B2 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE UNIVERSITY OF NEW JERSEY (US) | 2006-01-31 | — | — | US | disclosed |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2004-05-27 | — | — | US | disclosed |
| WO-2004014906-A2 | NITRO AND AMINO SUBSTITUTED DIBENZONAPHTHYRIDINES AS TOPOISOMERASE AGENTS | RUTGERS, THE STATE UNIVERSITY (US) | 2004-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045538-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | HTR1A 2567/4885ADRA1D 2545/4885ADRA1A 2182/4885 |
| US-20040102443-A1 | Nitro and amino substituted topoisomerase agents | TOP1, TOP2A, TOP2B | HTR1A 1558/4885ADRA1D 1201/4885ADRA1A 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.