Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.44 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4910336 | 0.92 | ALDH1A1 (0.51) | MAPK1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL4913809 | 0.88 | ALDH1A1 (0.51) | MAPK1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL4911365 | 0.88 | KCNN2 (0.57) | MAPK1ALDH1A1CYP3A4TSHRCYP2D6 | |
| SCHEMBL4908801 | 0.87 | KCNN2 (0.59) | MAPK1ALDH1A1TLR7KCNN2KCNN3 | |
| SCHEMBL4913903 | 0.87 | KCNN2 (0.59) | MAPK1ALDH1A1TLR7KCNN2KCNN3 | |
| SCHEMBL4912379 | 0.87 | KCNN2 (0.59) | MAPK1ALDH1A1TLR7KCNN2KCNN3 | |
| SCHEMBL4913744 | 0.85 | KDM4E (0.48) | MAPK1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL4911767 | 0.85 | CYP1A2 (0.55) | MAPK1ALDH1A1CYP1A2CYP3A4TSHR | |
| SCHEMBL4913876 | 0.83 | GBA1 (0.55) | MAPK1ALDH1A1CYP3A4KCNN2KCNN3 | |
| SCHEMBL4908142 | 0.76 | TDP1 (0.64) | MAPK1ALDH1A1TSHRALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861388-B1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | SANIONA AS (DK) | 2017-07-05 | — | — | EP | claimed |
| US-8252806-B2 | 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-propylamine; 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-(4-morpholin-4-yl-phenyl)-amine; respiratory diseases, epilepsy, convulsions, seizures, gastrointestinal dysfunction, ischaemia, psychosis, schizophrenia, anxiety, depression, Alzheimer's disease | NEUROSEARCH A/S (DK) | 2012-08-28 | — | — | US | claimed |
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | NEUROSEARCH A/S (DK) | 2008-11-06 | — | — | US | claimed |
| EP-1861388-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2007-12-05 | — | — | EP | claimed |
| WO-2006097441-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-09-21 | — | — | WO | claimed |
| EP-1861388-B1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | SANIONA AS (DK) | 2017-07-05 | — | — | EP | disclosed |
| US-8252806-B2 | 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-propylamine; 2-(3,5-Dimethyl-pyrazol-1-yl)-quinazolin-4-yl]-(4-morpholin-4-yl-phenyl)-amine; respiratory diseases, epilepsy, convulsions, seizures, gastrointestinal dysfunction, ischaemia, psychosis, schizophrenia, anxiety, depression, Alzheimer's disease | NEUROSEARCH A/S (DK) | 2012-08-28 | — | — | US | disclosed |
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | NEUROSEARCH A/S (DK) | 2008-11-06 | — | — | US | disclosed |
| EP-1861388-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097441-A1 | POTASSIUM CHANNEL MODULATING AGENTS AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275045-A1 | Potassium Channel Modulating Agents and Their Medical Use | KCND2, KCNN3, KCNJ2 | MAPK1 2608/4885ALDH1A1 3145/4885CYP1A2 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.