SCHEMBL491434

SCHEMBL491434

[CH](C1CCC1)C1CCC1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL300394 0.96
SCHEMBL491425 0.91 ALDH1A1 (0.36)
SCHEMBL11001515 0.87 ALDH1A1 (0.33)
SCHEMBL984941 0.87
SCHEMBL10494046 0.87 ALDH1A1 (0.33)
SCHEMBL6101790 0.87 ALDH1A1 (0.33)
SCHEMBL1173999 0.87 ALDH1A1 (0.33)
SCHEMBL22033837 0.87 ALDH1A1 (0.33)
SCHEMBL22033682 0.87 ALDH1A1 (0.33)
SCHEMBL1524657 0.87 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220024926-A1 A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-01-27 US claimed
CN-111362838-A Urea group-containing diimine palladium catalyst, ligand thereof and application thereof in olefin polymerization 中国科学技术大学 2020-07-03 CN claimed
WO-2020118139-A1 A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2020-06-11 WO claimed
US-20080171662-A1 Aminocarbonyl-Substituted Thiensulfonylamino(Thio)Carbonyl-Triazolin(Ethi)Ones, Processes For Their Preparation And Their Use BAYER CROPSCIENCE AG (DE) 2008-07-17 US claimed
EP-1776012-A1 AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF Bayer CropScience Aktiengesellschaft (DE) 2007-04-25 EP claimed
WO-2006012981-A1 AMINOCARBONYL-SUBSTITUTED THIENYLSULPHONYLUREAS BAYER CROPSCIENCE AG (DE) 2006-02-09 WO claimed
WO-2006012983-A1 AMINOCARBONYL-SUBSTITUTED THIENSULPHONYLAMINO (THIO) CARBONYLTRIAZOLIN (THI) ONES METHODS FOR PRODUCTION AND USE THEREOF BAYER CROPSCIENCE AG (DE) 2006-02-09 WO claimed
EP-1623987-A1 Fused pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and pyrido[3',2':4,5]furo[3,2-d]pyrimidines Curacyte Discovery GmbH (DE) 2006-02-08 EP claimed
WO-2006010568-A2 SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE CURACYTE DISCOVERY GMBH (DE) 2006-02-02 WO claimed
EP-1619196-A1 Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidines and Pyrido[3',2':4,5]furo[3,2-d]-pyrimidines for use as inhibitors of PDA-4 and/or TNF-alpha release Curacyte Discovery GmbH (DE) 2006-01-25 EP claimed
EP-1619197-A1 Substituted Pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-2,4(1H,3H)diones and -4(3H)ones as well as Pyrido[3',2':4,5]furo[3,2-d]-pyrimidin-2,4(1H,3H)diones und -4(3H)ones as inhibitors of TNF-alpha release Curacyte Discovery GmbH (DE) 2006-01-25 EP claimed
EP-1090005-B1 PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS BRISTOL MYERS SQUIBB PHARMA CO (US) 2003-08-20 EP claimed
US-6509338-B1 Psychiatric disorders and neurological diseases including affective disorder, anxiety, depression, headache, irritable bowel syndrome, post-traumatic stress disorder, supranuclear palsy, immune suppression, Alzheimer's disease, BRISTOL-MYERS SQUIBB COMPANY 2003-01-21 US claimed
EP-1090005-A1 PYRAZOLO 1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS Du Pont Pharmaceuticals Company (US) 2001-04-11 EP claimed
WO-1999067247-A1 PYRAZOLO[1,5-a]TRIAZINE CORTICOTROPIN RELEASING FACTOR ANTAGONISTS DU PONT PHARMACEUTICALS COMPANY (US) 1999-12-29 WO claimed
WO-2023111181-A1 SMALL MOLECULE MODULATORS OF IL-17 LEO PHARMA A/S (DK) 2023-06-22 WO disclosed
US-20220024926-A1 A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY,DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2022-01-27 US disclosed
US-4603012-A L-aminodicarboxylic acid alkanes GENERAL FOODS CORPORATION (US) 1986-07-29 US disclosed
US-4572799-A L-Aminodicarboxylic acid amides GENERAL FOODS CORPORATION (US) 1986-02-25 US disclosed
US-4571308-A L-Aminodicarboxylic acid aminoalkenoic acid ester amides GENERAL FOODS CORPORATION (US) 1986-02-18 US disclosed