SCHEMBL4915598

SCHEMBL4915598

COC(=O)[C]1CNCCO1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 1/20 0.44
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
CA7 P43166 1/20 0.31
CA9 Q16790 1/20 0.31
CA14 Q9ULX7 1/20 0.31
SSTR4 P31391 3/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SLC6A2 P23975 2/20 0.31
SLC6A4 P31645 2/20 0.31
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22684015 0.80 ACHE (0.33) CHRM3SSTR4
SCHEMBL4921794 0.80 ADORA1 (0.40) KDM4EALDH1A1CA12CA1CA2
SCHEMBL18228926 0.78
SCHEMBL3373469 0.75
SCHEMBL4914343 0.74
SCHEMBL19279864 0.74
SCHEMBL22683816 0.73 HTT (0.36) CHRM3SSTR4
SCHEMBL22684145 0.71
SCHEMBL497872 0.69
SCHEMBL4919714 0.69

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3740478-B1 FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2023-11-01 EP disclosed
CN-111601799-B Fused imidazole derivatives as Il-17 modulators UCB生物制药有限责任公司 2023-06-09 CN disclosed
US-11472794-B2 Fused imidazole derivatives as IL-17 modulators UCB Biopharma SRL (BE) 2022-10-18 US disclosed
US-20220227764-A1 Imidazopyridine Derivatives as IL-17 Modulators UCB BIOPHARMA SRL (SOCIETE A RESPONSABILITE LIMITEE) (BE) 2022-07-21 US disclosed
EP-3990459-A1 IMIDAZOPYRIDINE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2022-05-04 EP disclosed
EP-3990451-A1 FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2022-05-04 EP disclosed
CN-114026084-A Fused imidazole derivatives as IL-17 modulators UCB生物制药有限责任公司 2022-02-08 CN disclosed
CN-113906025-A Imidazopyridine derivatives as IL-17 modulators UCB生物制药有限责任公司 2022-01-07 CN disclosed
US-20210053952-A1 Fused Imidazole Derivatives as IL-17 Modulators UCB Biopharma SRL (BE) 2021-02-25 US disclosed
WO-2020261141-A1 IMIDAZOPYRIDINE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2020-12-30 WO disclosed
WO-2020260426-A1 FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2020-12-30 WO disclosed
WO-2020260425-A1 FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2020-12-30 WO disclosed
EP-3740478-A1 FUSED IMIDAZOLE DERIVATIVES AS IL-17 MODULATORS UCB Biopharma SRL (BE) 2020-11-25 EP disclosed
CN-111601799-A Fused imidazole derivatives as Il-17 modulators UCB生物制药有限责任公司 2020-08-28 CN disclosed
US-20080200475-A1 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors PFIZER INC. 2008-08-21 US disclosed
EP-1866317-A1 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS Pharmacia & Upjohn Company LLC (US) 2007-12-19 EP disclosed
WO-2006103555-A1 4-PIPERAZINOTHIENO [2, 3-D] PYRIMIDINE COMPOUNDS AS PLATELET AGGREGATION INHIBITORS PHARMACIA & UPJOHN COMPANY LLC (US) 2006-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11472794-B2 Fused imidazole derivatives as IL-17 modulators IL17A, IL2, IL23R CHRM3 4513/4885KDM4E 1817/4885ALDH1A1 1807/4885
US-20220227764-A1 Imidazopyridine Derivatives as IL-17 Modulators IL17A, IL2, IL23R CHRM3 4317/4885KDM4E 1820/4885ALDH1A1 1119/4885
US-20080200475-A1 4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors PF4, TBXA2R, P2RY4 CHRM3 455/4885KDM4E 2775/4885ALDH1A1 849/4885
US-20210053952-A1 Fused Imidazole Derivatives as IL-17 Modulators IL17A, IL2, IL23R CHRM3 4513/4885KDM4E 1817/4885ALDH1A1 1807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.